Phase 2 Risk Clinical Trials
96 recruitingPhase 2
What is a Phase 2 trial?
Phase 2 trials evaluate whether a treatment works for a specific condition and further assess its safety. These studies typically enroll several hundred participants and provide preliminary data on effectiveness.
Showing 1–20 of 96 trials
Recruiting
Phase 2
N10: A Study of Reduced Chemotherapy and Monoclonal Antibody (mAb)-Based Therapy in Children With Neuroblastoma
NeuroblastomaHigh Risk NeuroblastomaChildhood Neuroblastoma
Memorial Sloan Kettering Cancer Center45 enrolled1 locationNCT06528496
Recruiting
Phase 1Phase 2
Study of AZD3632 Monotherapy or in Combination With Anticancer Agents in Participants With Advanced Haematologic Malignancies With KMT2Ar, NPM1m, or Other Genotypes Associated With HOX Overexpression
Acute Lymphoblastic LeukaemiaHigher Risk Myelodysplastic SyndromesAcute Myeloid Leukaemia
AstraZeneca84 enrolled30 locationsNCT07155226
Recruiting
Phase 2
Immuno-PRISM (PRecision Intervention Smoldering Myeloma)
Multiple MyelomaSmoldering Multiple MyelomaHigh Risk Smoldering Multiple Myeloma
Irene Ghobrial, MD52 enrolled3 locationsNCT05469893
Recruiting
Phase 2
ctDNA-Guided De-Escalation of Adjuvant Chemotherapy With Dalpiciclib in HR-Positive/HER2-Negative Breast Cancer
HER2-negative Breast CancerBreast Cancer Early Stage Breast Cancer (Stage 1-3)Hormone Receptor-Positive Breast Cancer+3 more
Peking University People's Hospital393 enrolled1 locationNCT06970912
Recruiting
Phase 2
CDK4/6 Inhibitors Combined With Endocrine Therapy for Neoadjuvant Treatment
HER2-negative Breast CancerHormone Receptor-Positive Breast CancerEarly Stage Breast Cancer+2 more
Peking University People's Hospital158 enrolled1 locationNCT07366112
Recruiting
Phase 2
Mindful Walking Neural Correlates of Executive Function in SC Older Adults at Risk of Dementias
Older Adults With Elevated Dementia Risk
University of South Carolina54 enrolled1 locationNCT07638046
Recruiting
Phase 2
Intravenous Fish Oil Based Lipid Emulsion to Enhance Recovery in High-Risk Cardiac Surgery Patients
Coronary Artery Bypass Grafting (CABG)Cardiopulmonary BypassIntensive Care Unit+9 more
GCP-Service International West GmbH550 enrolled10 locationsNCT06279793
Recruiting
Phase 2
SCRT+mFOLFOX6+PD-1 Antibody and Targeted Therapy for High-Risk pMMR/MSS Rectal Cancer(CRIT)
Rectal AdenocarcinomaHigh-Risk CancerMSS
Sixth Affiliated Hospital, Sun Yat-sen University49 enrolled1 locationNCT06908031
Recruiting
Phase 2Phase 3
A Safety and Efficacy Study of hu14 in High-Risk Neuroblastoma Patients
High Risk Neuroblastoma
Renaissance Pharma Ltd.144 enrolled5 locationsNCT07549321
Recruiting
Phase 2
High Cardiovascular Risk Intervention With Cardio-Oncology Consultation for Prostate Cancer Following Androgen Receptor Pathway Inhibitor (ARPI) Therapy (Heart-Safe)
Prostate Cancer (Diagnosis)CV RiskProstate Cancer Stage IV
Cedars-Sinai Medical Center80 enrolled1 locationNCT07223385
Recruiting
Phase 2
Myeloablative Allo HSCT With Related or Unrelated Donor for Heme Disorders
Acute Lymphoblastic LeukemiaAcute Myeloid LeukemiaChronic Lymphocytic Leukemia+25 more
Masonic Cancer Center, University of Minnesota300 enrolled1 locationNCT03314974
Recruiting
Phase 2
A Study to Learn How Well a Combination of Darolutamide and Androgen Deprivation Therapy (ADT) Works as a Treatment Before Surgery for Men Who Have High-risk Localized Prostate Cancer.
High-Risk Localized Prostate Cancer
Bayer250 enrolled23 locationsNCT07450599
Recruiting
Phase 2
A Multicenter, Randomized Controlled Phase II Study of Short-Course Radiotherapy Followed by Sequential PD-1 Inhibitor and FOLFOX Chemotherapy Versus Long-Course Chemoradiotherapy for High-Risk Locally Advanced pMMR/MSS Lower Rectal Adenocarcinoma (STAR Trial)
Rectal AdenocarcinomaImmunotherapyHigh-risk Locally Advanced+2 more
Sixth Affiliated Hospital, Sun Yat-sen University76 enrolled1 locationNCT07669220
Recruiting
Phase 1Phase 2
Study to Evaluate CCS1477 (Inobrodib) in Haematological Malignancies
Acute Myeloid LeukemiaNon-Hodgkin LymphomaMultiple Myeloma+3 more
CellCentric Ltd.250 enrolled39 locationsNCT04068597
Recruiting
Phase 2
Venetoclax Combined With Azacitidine for Consolidation Therapy in AML
Acute Myeloid LeukemiaConsolidation TherapyHigh-Risk+2 more
The First Affiliated Hospital of Soochow University216 enrolled1 locationNCT07425782
Recruiting
Phase 2
VA Consolidation in Intermediate-Risk AML
Acute Myeloid LeukemiaConsolidation TherapyIntermediate Risk Acute Myeloid Leukemia
The First Affiliated Hospital of Soochow University226 enrolled1 locationNCT07672262
Recruiting
Phase 2
BRE-04: Window of Opportunity Trial of Preoperative Low Dose Azacitidine in High-Risk Early Stage Breast Cancer
Breast Cancer InvasiveHigh Risk Breast CarcinomaEarly Stage Breast Cancer
University of Illinois at Chicago40 enrolled1 locationNCT04891068
Recruiting
Phase 2
A Phase 2 Study to Evaluate the Pharmacodynamics, Safety and Tolerability of BGE-102 in Participants With Obesity and Cardiovascular Risk Factors
Obesity and Cardiovascular Risk
BioAge Labs, Inc.160 enrolled13 locationsNCT07656727
Recruiting
Phase 2
Neoadjuvant ADT + Darolutamide With Pembrolizumab, Followed by Adjuvant Pembrolizumab in Molecularly Stratified High-Risk Prostate Cancer
Prostate CancerHigh-risk Prostate Cancer
Icahn School of Medicine at Mount Sinai40 enrolled1 locationNCT07027124
Recruiting
Phase 1Phase 2
Cladribine, Idarubicin, Cytarabine, and Quizartinib in Treating Patients With Newly Diagnosed, Relapsed, or Refractory Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome
Acute Myeloid LeukemiaHigh Risk Myelodysplastic SyndromeRecurrent Acute Myeloid Leukemia+5 more
M.D. Anderson Cancer Center80 enrolled1 locationNCT04047641