Rotator Cuff Clinical Trials

121 recruitingLast updated: June 26, 2026

There are 121 actively recruiting rotator cuff clinical trials across 27 countries. Studies span Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3. Top locations include Istanbul, Turkey (Türkiye), Chicago, Illinois, United States, Beijing, Beijing Municipality, China. Updated daily from ClinicalTrials.gov.


Rotator Cuff Trials at a Glance

121 actively recruiting trials for rotator cuff are listed on ClinicalTrialsFinder across 6 cities in 27 countries. The largest study group is Not Applicable with 77 trials, with the heaviest enrollment activity in Istanbul, Chicago, and Beijing. Lead sponsors running rotator cuff studies include Peking University Third Hospital, Gazi University, and FX Shoulder Solutions.

Browse rotator cuff trials by phase

Treatments under study

About Rotator Cuff Clinical Trials

Looking for clinical trials for Rotator Cuff? There are currently 2 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Rotator Cuff trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Rotator Cuff clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 121 trials

Recruiting
Phase 2

Efficacy and Safety Study of TPX-115 on Partial-thickness Rotator Cuff Tear

Partial Thickness Rotator Cuff Tears
Tego Science, Inc.60 enrolled3 locationsNCT07219654
Recruiting
Not Applicable

Effect of Mobilization With Movement in Patients With Rotator Cuff Lesions

Physical DisabilityRotator Cuff Tears
Kirsehir Ahi Evran Universitesi75 enrolled1 locationNCT07383038
Recruiting
Not Applicable

SINEFIX-2022 Comparative Phase

Rotator Cuff Tears of the Shoulder
BAAT Medical Products B.V.60 enrolled2 locationsNCT06818448
Recruiting

Evaluation Of Outcomes Following Rotator Cuff Repair Using the REGENETEN Bioinductive Implant

rotator cuff injuries
Smith & Nephew, Inc.400 enrolled22 locationsNCT06857084
Recruiting
Not Applicable

Effects Of Biceps Transposition Without Tenotomy For Augmentation Of Massive Rotator Cuff Repairs

Massive rotator cuff tear
Ataturk University35 enrolled1 locationNCT07375277
Recruiting

The Role of Pectoralis Minor Tightness in the Development of Rotator Cuff Tears

Shoulder impingement syndromePectoralis Minor TightnessPectoralis Minor Muscle Tension+1 more
Gazi University90 enrolled1 locationNCT07228936
Recruiting

Long-Term Follow-up Study to Evaluate Long-Term Safety and Efficacy of Allogenic Umbilical Cord-derived Mesenchymal Stem Cell in Patients With Rotator Cuff Disease

Rotator Cuff Disease
Seoul National University Hospital21 enrolled1 locationNCT07374679
Recruiting
Not Applicable

Effectiveness of Core Stabilization Exercises in Rotator Cuff Injuries

Rotator Cuff Injury (RCI)Core Exercises Training
Ahi Evran University Education and Research Hospital69 enrolled1 locationNCT07377292
Recruiting

Post-Market Clinical Follow-up (PMCF) Study of the Pitch-Patch for the Augmentation or Reinforcement of the Rotator Cuff

Rotator Cuff TearsRotator Cuff tearRotator Cuff Tears of the Shoulder+1 more
Xiros Ltd37 enrolled1 locationNCT05906004
Recruiting
Phase 4

Rotator Cuff Tears Repair With or Without Dermal Patch Augmentation

Rotator Cuff Tears
University Hospitals, Leicester40 enrolled1 locationNCT04975581
Recruiting
Not Applicable

Exercise-induced Hypoalgesia Effects of Blood Flow Restriction in People With Rotator Cuff-related Shoulder Pain

Rotator Cuff-related Shoulder Pain
University of Valencia30 enrolled1 locationNCT07232511
Recruiting
Phase 1Phase 2

Effects of Allogenic Umbilical Cord-Derived Mesenchymal Stem Cells on Patients With Rotator Cuff Disease

Rotator Cuff Disease
Seoul National University Hospital21 enrolled1 locationNCT06794294
Recruiting
Not Applicable

Prospective Study to Determine the Safety and Effectiveness of a Connective Tissue Allograft Active Matrix (AM) vs. Standard of Care in Arthroscopic Rotator Cuff Repair

Rotator Cuff Tears
The University of Texas Health Science Center, Houston72 enrolled1 locationNCT05894265
Recruiting

Long Term Clinical Outcome After Arthroscopic Rotator Cuff Repair Augmentation With Autologous Microfragmented Lipoaspirate Tissue

AugmentationArthroscopic Rotator Cuff RepairMicrofragmented Adipose Tissue
University of Milan52 enrolled1 locationNCT06960343
Recruiting

RETRO-PROSPECTIVE POSTMARKET CLINICAL STUDY FOR FX SHOULDER SOLUTIONS SHOULDER SYSTEMS

Glenohumeral OsteoarthritisAvascular Necrosis of the Head of HumerusInflammatory Arthritis+4 more
FX Solutions1,004 enrolled22 locationsNCT07558590
Recruiting
Not Applicable

Effect of Motor Imagery Training on Pain, Functionality, Proprioception and Kinesiophobia in Partial Rotator Cuff Tear

Rotator Cuff Tears
Kutahya Health Sciences University80 enrolled1 locationNCT06875895
Recruiting
Not Applicable

The Effect of an Exercise Program Based on Attentional Focus Shifting on Clinical Outcomes in Rotator Cuff Related Shoulder Pain

Shoulder tendinopathyShoulder bursitisSubacromial Pain Syndrome+2 more
Istanbul University46 enrolled1 locationNCT07546084
Recruiting
Not Applicable

BioBrace® Implant for Arthroscopic Repair of Full Thickness Rotator Cuff Tears

Rotator Cuff Tears
CONMED Corporation268 enrolled1 locationNCT05997381
Recruiting

Pain Education After Rotator Cuff Surgery

Postoperative Pain ManagementRotator Cuff TearsKinesiophobia (Fear of Movement)+2 more
Elif Dilara Durmaz45 enrolled1 locationNCT06886932
Recruiting
Not Applicable

The Effect of a Dual-Task Technique-Based Exercise Program on Clinical Outcomes in Rotator Cuff Related Shoulder Pain

Subacromial Pain SyndromeRotator Cuff-related Shoulder PainShoulder Pain Syndrome
Istanbul University46 enrolled1 locationNCT07415967