Phase 1 SCI Clinical Trials
24 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 24 trials
Recruiting
Phase 1Phase 2
Lentiviral Gene Transfer for Treatment of Children Older Than Two Years of Age With X-Linked Severe Combined Immunodeficiency (XSCID)
X-linked Severe Combined Immunodeficiency (XSCID)
National Institute of Allergy and Infectious Diseases (NIAID)40 enrolled1 locationNCT01306019
Recruiting
Phase 1Phase 2
Double Dose 4-AP on Functional Recovery After Spinal Cord Injury
SCI - Spinal Cord Injury
Shirley Ryan AbilityLab27 enrolled1 locationNCT06853015
Recruiting
Phase 1
Study to Evaluate Safety of C-1101 Versus Sterile Saline in Adults With Chronic Painful Lumbosacral Radiculopathy
Lumbosacral RadiculopathySciaticaSciatic Radiculopathy+3 more
Consano Bio24 enrolled3 locationsNCT07264270
Recruiting
Phase 1Phase 2
Intraperitoneal SK-NK Cell Injection for Advanced Ovarian Cancer With Massive Ascites
AscitesOvarian Neoplasms Malignant
Cancer Institute and Hospital, Chinese Academy of Medical Sciences29 enrolled1 locationNCT07435701
Recruiting
Phase 1
A Study of GensSci098 in Subjects With Graves' Disease
SafetyGraves DiseaseTolerability+1 more
Changchun GeneScience Pharmaceutical Co., Ltd.24 enrolled1 locationNCT07286656
Recruiting
Phase 1
A Study of GenSci098 in Subjects With Active Thyroid Eye Disease
SafetyTolerabilityGenSci098+1 more
Changchun GeneScience Pharmaceutical Co., Ltd.76 enrolled1 locationNCT06569758
Recruiting
Phase 1
Lateral Plantar Artery Embolization For Plantar Fasciitis
Plantar fasciitisPlantar Fasciitis, Chronic
Joint & Vascular Institute10 enrolled1 locationNCT07395128
Recruiting
Phase 1Phase 2
Intraperitoneal Injection of Liposomal Irinotecan as Monotherapy or in Combination With Recombinant Mutant Human Tumor Necrosis Factor or Bevacizumab for the Treatment of Malignant Ascites Following Failure of Prior Standard Therapy
Malignant ascites
Dong sheng Zhang48 enrolled1 locationNCT07397819
Recruiting
Phase 1Phase 2
A Prospective, Multicenter, Phase Ib/II Trial of Ivonescimab (AK112) Combined With Albumin-Paclitaxel and Cisplatin as Neoadjuvant Therapy for ESCC
Esophageal Squamous Cell CarcinomaNeoadjuvantIvonescimab
Tang-Du Hospital45 enrolled1 locationNCT07385001
Recruiting
Phase 1Phase 2
A First-in-Human, Open-Label, Dose-Escalation Study to Evaluate the Safety and Tolerability of Gene Therapy With TTX-381 for the Ocular Manifestations Associated With Neuronal Ceroid Lipofuscinosis Type 2 (CLN2) Disease
Neuronal Ceroid Lipofuscinosis Type 2
Tern Therapeutics, LLC16 enrolled2 locationsNCT05791864
Recruiting
Phase 1Phase 2
Intraperitoneal Immune Checkpoint Inhibitors and Zoledronic Acids for Gastric Cancer Malignant Ascites
Ascites, MalignantCancer of Stomach, Adenocarcinoma
Qilu Hospital of Shandong University24 enrolled1 locationNCT06759064
Recruiting
Phase 1Phase 2
SCID-X1 Gene Therapy Via Intravenous Lentiviral (Ivlv-X1) Injection
SCID, X-Linked
Shenzhen Geno-Immune Medical Institute10 enrolled2 locationsNCT03217617
Recruiting
Phase 1
Single and Multiple Dose Escalation of PHIN-214 in Child-Pugh A and B Liver Cirrhotics
Cirrhosis, LiverLiver FibrosisAscites Hepatic
PharmaIN74 enrolled9 locationsNCT05490888
Recruiting
Phase 1Phase 2
Phase 1b/2a Clinical Trial to Determine the Safety, Tolerability and Efficacy of TZ-161 in Spinal Cord Injury
Acute Spinal Cord Injury (SCI)
Technophage, SA28 enrolled2 locationsNCT06677229
Recruiting
Phase 1Phase 2
Effects of CBD/CBD-A Oral Extract on Resting-state EEG and Neuropathic Pain Symptoms After SCI
Neuropathic PainSCI - Spinal Cord Injury
University of Miami20 enrolled1 locationNCT05630235
Recruiting
Phase 1
A Phase I Study of SIM0388 in Participants With Malignant Ascites.
Malignant ascites
Jiangsu Simcere Pharmaceutical Co., Ltd.50 enrolled1 locationNCT07007988
Recruiting
Phase 1
Exploring the Utility of [18F]3F4AP for Demyelination Imaging
Alzheimer's Disease(AD)MCIDemyelinating Disorders+3 more
Yale University105 enrolled1 locationNCT06999434
Recruiting
Phase 1
Tocilizumab Delivered Via Pleural and Peritoneal Catheters in Patients With Advanced Metastatic Cancer
Malignant Pleural EffusionMalignant ascites
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)12 enrolled1 locationNCT06016179
Recruiting
Phase 1
NG004 in Spinal Cord Injury Patients
Central Nervous System DiseasesNervous System DiseasesTrauma, Nervous System+4 more
NovaGo Therapeutics AG21 enrolled6 locationsNCT06817577
Recruiting
Phase 1
The Neurobiological Effect of 5-HT2AR Modulation
Basic Science
Gitte Moos Knudsen200 enrolled1 locationNCT03289949