Phase 3 Sickle Cell Disease Clinical Trials
9 recruitingPhase 3
What is a Phase 3 trial?
Phase 3 trials compare the new treatment against the current standard of care in large groups, often hundreds to thousands of participants. Successful Phase 3 results are typically required for regulatory approval.
Showing 1–9 of 9 trials
Recruiting
Phase 3
A Study to Investigate the Efficacy and Safety of Crizanlizumab (5 mg/kg) Compared With Placebo in Adolescent and Adult Sickle Cell Disease Patients Who Experience Frequent Vaso-Occlusive Crises (SPARKLE)
Sickle Cell Disease
Novartis Pharmaceuticals315 enrolled31 locationsNCT06439082
Recruiting
Phase 3
The Efficacy and Safety of Rilzabrutinib in Participants Aged 10 to 65 Years With Sickle-cell Disease
Sickle Cell Disease
Sanofi192 enrolled54 locationsNCT06975865
Recruiting
Phase 3
A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease
Sickle Cell Disease
Novo Nordisk A/S408 enrolled172 locationsNCT06612268
Recruiting
Phase 3
Study of a Single Dose of a 21-valent Pneumococcal Conjugate Vaccine in Children and Adolescents With Sickle Cell Disease
Sickle Cell Disease
Sanofi100 enrolled7 locationsNCT07247188
Recruiting
Phase 3
A Research Study Looking at Long-term Treatment With Etavopivat in People With Sickle Cell Disease or Thalassaemia
Sickle Cell DiseaseThalassemia
Novo Nordisk A/S480 enrolled103 locationsNCT06609226
Recruiting
Phase 2Phase 3
A Phase 2/3 Study in Adult and Adolescent Participants With SCD
Sickle Cell Disease
Pfizer389 enrolled49 locationsNCT05431088
Recruiting
Phase 3
Evaluation of Efficacy and Safety of a Single Dose of CTX001 in Participants With Transfusion-Dependent β-Thalassemia and Severe Sickle Cell Disease
Beta-ThalassemiaSickle Cell DiseaseHematologic Diseases+4 more
Vertex Pharmaceuticals Incorporated26 enrolled6 locationsNCT05477563
Recruiting
Phase 3
Promoting Utilization and Safety of Hydroxyurea Using Precision in Africa
Sickle Cell DiseaseSickle Cell Anemia in Children
Brown University400 enrolled1 locationNCT05285917
Recruiting
Phase 3
RElated Haplo-DonoR Haematopoietic stEm Cell Transplantation for Adults With Severe Sickle Cell Disease
Sickle Cell Disease
King's College Hospital NHS Trust120 enrolled1 locationNCT05392894