Phase 2 Sickle Cell Disease Clinical Trials
34 recruitingPhase 2
What is a Phase 2 trial?
Phase 2 trials evaluate whether a treatment works for a specific condition and further assess its safety. These studies typically enroll several hundred participants and provide preliminary data on effectiveness.
Showing 1–20 of 34 trials
Recruiting
Phase 2
Safety, Efficacy, and Pharmacokinetics of CSL889 in Adults and Adolescents With Sickle Cell Disease During Vaso-Occlusive Crisis
Sickle Cell Disease Vaso-occlusive Crisis
CSL Behring70 enrolled17 locationsNCT06699849
Recruiting
Phase 2
Nonmyeloablative Stem Cell Transplant in Children With Sickle Cell Disease and a Major ABO-Incompatible Matched Sibling Donor
Sickle Cell DiseaseStem Cell Transplant ComplicationsPure Red Cell Aplasia+1 more
University of Calgary12 enrolled1 locationNCT03214354
Recruiting
Phase 1Phase 2
A Phase I/II Study of ITU512 in Healthy Participants and Patients With Sickle Cell Disease
Sickle Cell Disease
Novartis Pharmaceuticals161 enrolled3 locationsNCT06546670
Recruiting
Phase 2
A Study to Evaluate the Pharmacokinetics and Safety of Etavopivat in Pediatric Patients With Sickle Cell Disease
Sickle Cell Disease
Forma Therapeutics, Inc.95 enrolled18 locationsNCT06198712
Recruiting
Phase 1Phase 2
Transplantation of Clustered Regularly Interspaced Short Palindromic Repeats Modified Hematopoietic Progenitor Stem Cells (CRISPR_SCD001) in Patients With Severe Sickle Cell Disease
Sickle Cell Disease
Mark Walters, MD9 enrolled2 locationsNCT04774536
Recruiting
Phase 2
Alendronate for Osteonecrosis in Adults With Sickle Cell Disease
Sickle Cell DiseaseOsteonecrosisAvascular Necrosis+2 more
University of California, Davis30 enrolled1 locationNCT06016634
Recruiting
Phase 2
Intravenous L-Citrulline for Vaso-occlusive Pain Episode in Sickle Cell Disease
Sickle Cell DiseaseVaso-occlusive Pain Episode
Suvankar Majumdar99 enrolled1 locationNCT06635902
Recruiting
Phase 2
A Study of Immune Suppression Treatment for People With Sickle Cell Disease or β-Thalassemia Who Are Going to Receive an Allogeneic Hematopoietic Cell Transplantation (HCT)
Sickle Cell Disease
Memorial Sloan Kettering Cancer Center24 enrolled6 locationsNCT05736419
Recruiting
Phase 2
Tocilizumab for Acute Chest Syndrome
Sickle Cell DiseaseAcute Chest Syndrome
University of Chicago200 enrolled1 locationNCT05640271
Recruiting
Phase 2
A Dose-Finding Study of Tebapivat to Assess Efficacy, and Safety in Participants With Sickle Cell Disease (SCD)
Sickle Cell Disease
Agios Pharmaceuticals, Inc.56 enrolled32 locationsNCT06924970
Recruiting
Phase 2Phase 3
A Phase 2/3 Study in Adult and Adolescent Participants With SCD
Sickle Cell Disease
Pfizer389 enrolled49 locationsNCT05431088
Recruiting
Phase 2
Losartan for Diffuse Myocardial Fibrosis in Sickle Cell Disease
Sickle Cell DiseaseDiffuse Myocardial Fibrosis
Children's Hospital Medical Center, Cincinnati24 enrolled1 locationNCT05012631
Recruiting
Phase 2
Allo HSCT for High Risk Hemoglobinopathies
Sickle Cell DiseaseHemoglobinopathiesGraft Failure
Masonic Cancer Center, University of Minnesota62 enrolled1 locationNCT06872333
Recruiting
Phase 2
Zinc Supplementation in Sickle Cell Disease: A Precursor to the Think Zinc for Bones Trial
Sickle Cell Disease
University of California, San Francisco34 enrolled6 locationsNCT06260891
Recruiting
Phase 1Phase 2
Gene Correction in Autologous CD34+ Hematopoietic Stem Cells (HbS to HbA) to Treat Severe Sickle Cell Disease
Sickle Cell Disease
Kamau Therapeutics15 enrolled4 locationsNCT04819841
Recruiting
Phase 2
Minimizing Toxicity in HLA-identical Sibling Donor Transplantation for Children With Sickle Cell Disease
Sickle Cell Disease
Robert Nickel100 enrolled7 locationsNCT03587272
Recruiting
Phase 2
Sub-dissociative Dose Ketamine in Treatment of Vaso-occlusive Pain Event in Children and Young Adults
Pain ManagementSickle Cell DiseaseVaso-Occlusive Crises+2 more
Mohsen Saidinejad120 enrolled1 locationNCT07369024
Recruiting
Phase 1Phase 2
Efficacy Safety Study of Gene Therapy for Sickle Cell DiseaseSCD Using Autologous CD34+ Cells Transduced ex Vivo, Carrying a Corrected Globin Gene and a Silencing RNA.
Sickle Cell Disease
Assistance Publique - Hôpitaux de Paris15 enrolled1 locationNCT07432867
Recruiting
Phase 2
Cognitive Remediation Intervention to Prepare for Transition of Care
Cognitive ImpairmentSickle Cell DiseaseSelf Efficacy+3 more
University of Alabama at Birmingham120 enrolled1 locationNCT05336201
Recruiting
Phase 2
Safety of Anumigilimab (CSL324) in Adults With Sickle Cell Disease (SCD)
Sickle Cell Disease
CSL Behring63 enrolled3 locationsNCT07224360