Phase 1 Spastic Clinical Trials
9 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–9 of 9 trials
Recruiting
Phase 1Phase 2
A Study to Assess the Safety and Efficacy of IPN10200 in Adult Participants With Upper Limb Spasticity.
Spasticity
Ipsen240 enrolled81 locationsNCT04752774
Recruiting
Phase 1
Shockwave for Elbow and Wrist Spasticity in People With Spinal Cord Injury
Spinal Cord InjurySpasticityShockwave Therapy
Kessler Foundation12 enrolled1 locationNCT07501429
Recruiting
Phase 1
Low or High Botox Dilution for the Hemiplegic Gait?
Post Stroke Spastic Hemiplegia
University of Ioannina20 enrolled1 locationNCT04630873
Recruiting
Phase 1Phase 2
Melpida: Recombinant Adeno-associated Virus (serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt)
Spasticity, MuscleSpastic ParaplegiaMicrocephaly+3 more
Elpida Therapeutics SPC4 enrolled1 locationNCT05518188
Terminated
Phase 1
Comparative, Multiple-Dose, Fixed Sequence, Pharmacokinetic Study of 2 Sizes of Daily MRX-4TZT TDS (Tizanidine Transdermal Delivery System) Applied for 3 Days and 2 Dose Levels of Oral Tizanidine in Healthy Adult Subjects
Spasticity
MEDRx Australia Pty Ltd24 enrolled1 locationACTRN12624001134516
Completed
Phase 1
A Randomized, Double-Blind, Placebo-Controlled, Multiple-Dose Study to Assess the Safety and Pharmacokinetics of CHI-541 among Healthy Participants
Muscle SpasticityPainEpilepsy+1 more
10607410 CANADA INC. DBA Spectrum Therapeutics40 enrolled1 locationACTRN12619001723178
Completed
Phase 1
A Randomized, Double-Blind, Placebo-Controlled, Multiple-Dose Study to Assess the Safety and Pharmacokinetics of CHI-936 in Healthy Participants
Muscle SpasticityPainEpilepsy+1 more
10607410 CANADA INC. DBA Spectrum Therapeutics40 enrolled1 locationACTRN12619001450101
Terminated
Phase 1
A trial to evaluate the effect of FLX-787 ODT on Motor Neuron Disease.
Spasticity & cramps in patients with Motor Neuron Disease
Flex Pharma, Inc50 enrolled3 locationsACTRN12616001060437
Completed
Phase 1
A Randomised, Cross-over Study to Evaluate Efficacy and Tolerability of FLX-787 in Patients with Multiple Sclerosis spasticity and spasms/cramps
Spasticity & cramps in patients with MS
Flex Pharma, Inc80 enrolled8 locationsACTRN12616000714482