Spine Clinical Trials

141 recruitingLast updated: June 18, 2026

There are 141 actively recruiting spine clinical trials across 32 countries. Studies span Not Applicable, Phase 4, Phase 2, Phase 1, Phase 3. Top locations include Boston, Massachusetts, United States, New York, New York, United States, Philadelphia, Pennsylvania, United States. Updated daily from ClinicalTrials.gov.


Spine Trials at a Glance

141 actively recruiting trials for spine are listed on ClinicalTrialsFinder across 6 cities in 32 countries. The largest study group is Not Applicable with 71 trials, with the heaviest enrollment activity in Boston, New York, and Philadelphia. Lead sponsors running spine studies include Istituto Ortopedico Rizzoli, Balgrist University Hospital, and Kafrelsheikh University.

Browse spine trials by phase

Treatments under study

About Spine Clinical Trials

Looking for clinical trials for Spine? There are currently 6 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Spine trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Spine clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 141 trials

Recruiting

The Effect of Peloidotherapy in Young Adults Undergoing Physical Therapy Scoliosis Specific Exercises (PSSE)

Spine DeformityPeloidotherapyAdult Scoliosis
Gaziosmanpasa Research and Education Hospital54 enrolled1 locationNCT07459400
Recruiting
Phase 2

Single- vs. Two-Fraction Spine Stereotactic Radiosurgery for the Treatment of Vertebral Metastases

Spine MetastasesSpine Stereotactic Radiosurgery (sSRS)
Case Comprehensive Cancer Center130 enrolled1 locationNCT04218617
Recruiting
Not Applicable

FIBERGRAFT Aeridyan Posterolateral Fusion Study

Degenerative Spine Disease
DePuy Synthes Products, Inc.316 enrolled8 locationsNCT07059065
Recruiting
Not Applicable

Laser Interstitial Thermal Ablation and Stereotactic Radiosurgery for Patients With Spine Metastases

Spinal cord compressionSpine MetastasesNeoplasm Metastasis+2 more
Henry Ford Health System60 enrolled1 locationNCT05023772
Recruiting
Not Applicable

Rehabilitation With Empowered STrategies to Optimize REcovery

Lumbar Spine SurgeryLumbar Spine Degenerative Changes
Vanderbilt University Medical Center100 enrolled4 locationsNCT07406997
Recruiting
Phase 1Phase 2

LDGraft in Single Level Anterior Lumbar Interbody Fusion (ALIF)

Degenerative Disc DiseaseLumbar Spine DegenerationSpine Disease+1 more
Locate Bio Pty Ltd40 enrolled3 locationsNCT06462729
Recruiting
Not Applicable

Dynamic Compliance-Guided Ventilation in Lumbar Surgery

ventilator-induced lung injuryPostoperative ComplicationsLumbar Disc Herniation+1 more
Ankara City Hospital Bilkent72 enrolled1 locationNCT07349719
Recruiting
Not Applicable

Sevoflurane vs Propofol Anesthesia in Obese Patients Undergoing Lumbar Surgery

Obesity, OverweightLumbar Spine Surgery
Ataturk University70 enrolled1 locationNCT07611240
Recruiting
Not Applicable

The NOTICE Study: Neurosurgery and OrThopedIcs Communication Evaluation Study Following Lumbar Fusions

Lumbar SpondylosisLumbar Spine InstabilityLumbar Spine Degeneration
Duke University224 enrolled1 locationNCT04140344
Recruiting
Phase 4

The Effect of Zolpidem on Outcomes Following Lumbar Spine Fusion

Pain, PostoperativeSpine FusionLumbar Spine Degeneration+1 more
University of Southern California140 enrolled1 locationNCT05746143
Recruiting
Not Applicable

Pre-operative Risk Assessment Combined With Targeted Intervention in the Chinese Elderly With Spine Surgery II

PrehabilitationFrail ElderlyLumbar Degenerative Disease+2 more
Xuanwu Hospital, Beijing248 enrolled4 locationsNCT07396077
Recruiting
Not Applicable

An Open, Parallel-group, Randomized, Medical Device Study to Assess the Usability and Performance of Surgify HaloTM in Spine Surgery Versus State-of-art (Rosen Burr)

Spine Surgery
Surgify Medical Oy30 enrolled1 locationNCT06827795
Recruiting

ACSS Approach on Dysphagia

Anterior Cervical Spine Surgery
Hamilton Health Sciences Corporation100 enrolled1 locationNCT07533864
Recruiting

IVC Collapsibility Index in Lumbar Stabilization Surgery

Hemodynamic ChangesLumbar Spine SurgeryIntravascular Volume Status
Trabzon Kanuni Education and Research Hospital128 enrolled2 locationsNCT07549165
Recruiting
Not Applicable

Study of an Intrathecal Port and Catheter System for Subjects With Spinal Muscular Atrophy

Spinal Muscular AtrophyScoliosisSpine Deformity
Alcyone Therapeutics, Inc90 enrolled21 locationsNCT05866419
Recruiting
Phase 2

Risk Adapted Spinal Cord/Cauda Constraint Relaxation for High-risk Patients With Metastatic Epidural Spinal Cord Compression Undergoing Spine Stereotactic Radiosurgery

Spinal CordMetastatic EpiduralSpine Stereotactic
M.D. Anderson Cancer Center60 enrolled1 locationNCT06204315
Recruiting
Not Applicable

Clinical Study on the Safety and Efficacy of the Minimally Invasive Ennovate® Method for Pedicle Screw Placement

Pain, PostoperativeCervical Spine Disease
Aesculap AG76 enrolled3 locationsNCT06960018
Recruiting
Not Applicable

Study on Orthosis in Cervical Spine Fracture Treatment

cervical spine injuryCervical Spine FracturesRigid Collar
Uppsala University Hospital616 enrolled6 locationsNCT06848660
Recruiting
Not Applicable

Personalized Perioperative Analgesia Platform (PPAP) for Pediatric Spine Fusion Surgery (sIRB)

Spine FusionPPAP
Senthil Sadhasivam300 enrolled5 locationsNCT05367609
Recruiting

Effectiveness Of Radiofrequency Ablation And Stabilization In Metastatic Spine Lesions By Positron Emission Computed Tomography (PET-CT) Confirmation

Spine MetastasesRadiofrequency AblationBone Cancer Metastatic+1 more
National and Kapodistrian University of Athens16 enrolled1 locationNCT06716294