Spine Clinical Trials

6 recruiting

Spine Trials at a Glance

132 actively recruiting trials for spine are listed on ClinicalTrialsFinder across 6 cities in 31 countries. The largest study group is Not Applicable with 64 trials, with the heaviest enrollment activity in New York, Boston, and Philadelphia. Lead sponsors running spine studies include Istituto Ortopedico Rizzoli, Balgrist University Hospital, and Kafrelsheikh University.

Browse spine trials by phase

Treatments under study

About Spine Clinical Trials

Looking for clinical trials for Spine? There are currently 6 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Spine trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Spine clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 132 trials

Recruiting
Phase 4

The Effect of Zolpidem on Outcomes Following Lumbar Spine Fusion

Pain, PostoperativeSpine FusionLumbar Spine Degeneration+1 more
University of Southern California140 enrolled1 locationNCT05746143
Recruiting
Not Applicable

Pre-operative Risk Assessment Combined With Targeted Intervention in the Chinese Elderly With Spine Surgery II

PrehabilitationFrail ElderlyLumbar Degenerative Disease+2 more
Xuanwu Hospital, Beijing248 enrolled4 locationsNCT07396077
Recruiting
Not Applicable

An Open, Parallel-group, Randomized, Medical Device Study to Assess the Usability and Performance of Surgify HaloTM in Spine Surgery Versus State-of-art (Rosen Burr)

Spine Surgery
Surgify Medical Oy30 enrolled1 locationNCT06827795
Recruiting

ACSS Approach on Dysphagia

Anterior Cervical Spine Surgery
Hamilton Health Sciences Corporation100 enrolled1 locationNCT07533864
Recruiting

IVC Collapsibility Index in Lumbar Stabilization Surgery

Hemodynamic ChangesLumbar Spine SurgeryIntravascular Volume Status
Trabzon Kanuni Education and Research Hospital128 enrolled2 locationsNCT07549165
Recruiting
Not Applicable

Study of an Intrathecal Port and Catheter System for Subjects With Spinal Muscular Atrophy

Spinal Muscular AtrophyScoliosisSpine Deformity
Alcyone Therapeutics, Inc90 enrolled21 locationsNCT05866419
Recruiting
Phase 2

Risk Adapted Spinal Cord/Cauda Constraint Relaxation for High-risk Patients With Metastatic Epidural Spinal Cord Compression Undergoing Spine Stereotactic Radiosurgery

Spinal CordMetastatic EpiduralSpine Stereotactic
M.D. Anderson Cancer Center60 enrolled1 locationNCT06204315
Recruiting
Not Applicable

FIBERGRAFT Aeridyan Posterolateral Fusion Study

Degenerative Spine Disease
DePuy Synthes Products, Inc.316 enrolled8 locationsNCT07059065
Recruiting
Not Applicable

Clinical Study on the Safety and Efficacy of the Minimally Invasive Ennovate® Method for Pedicle Screw Placement

Pain, PostoperativeCervical Spine Disease
Aesculap AG76 enrolled3 locationsNCT06960018
Recruiting
Not Applicable

Study on Orthosis in Cervical Spine Fracture Treatment

Cervical Spine Fractures
Uppsala University Hospital616 enrolled6 locationsNCT06848660
Recruiting
Not Applicable

Personalized Perioperative Analgesia Platform (PPAP) for Pediatric Spine Fusion Surgery (sIRB)

Spine FusionPPAP
Senthil Sadhasivam300 enrolled5 locationsNCT05367609
Recruiting

Effectiveness Of Radiofrequency Ablation And Stabilization In Metastatic Spine Lesions By Positron Emission Computed Tomography (PET-CT) Confirmation

Spine MetastasesRadiofrequency AblationBone Cancer Metastatic+1 more
National and Kapodistrian University of Athens16 enrolled1 locationNCT06716294
Recruiting
Not Applicable

Vertebroplasty With Radiation Therapy for Spine Metastatic Cancer Patients With Indeterminate Lesion (SINS Criteria)

Malignant Solid NeoplasmHematopoietic and Lymphoid Cell NeoplasmMetastatic Malignant Neoplasm in the Spine
Ohio State University Comprehensive Cancer Center200 enrolled1 locationNCT05178472
Recruiting
Not Applicable

Three Dimensional Gait Analysis and Electromyography After Stabilisation of Thoracolumbar Spine Fractures Focusing on Possible Temporal Diferences in Physiological Gait Recovery Through Comparison of Open and Minimally Invasive Approaches.

Spine Fracture
Masarykova Nemocnice v Usti nad Labem, Krajska Zdravotni a.s.20 enrolled1 locationNCT07516834
Recruiting
Not Applicable

Early Mobilization Following Elective Spine Surgery: Trial of In-bed Cycling

SpinePost Surgery PatientsRecovery Method
Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal88 enrolled1 locationNCT07506720
Recruiting

Evaluation of Medication Tapering on the Sensitivity of the Spinal Cord Using Closed-Loop Spinal Cord Stimulation (Pilot Study)

Neurophysiological Sensitivity to Spinal Cord StimulationFailed Back Surgery Syndrome (FBSS)Persistent Spinal Pain Syndrome Type 2 (PSPS-T) Lower Spine
Brai²n20 enrolled1 locationNCT07502612
Recruiting

Post-Market Clinical Follow-Up Study on the Safety and Performance of Ennovate® Cervical

Degenerative Disc DiseaseSpinal TumorSpine Fracture+2 more
Aesculap AG200 enrolled4 locationsNCT05296889
Recruiting
Not Applicable

Rehabilitation With Empowered STrategies to Optimize REcovery

Lumbar Spine SurgeryLumbar Spine Degenerative Changes
Vanderbilt University Medical Center100 enrolled4 locationsNCT07406997
Recruiting

Molecular and Genetic Studies of Congenital Myopathies

Nemaline MyopathyCentronuclear MyopathyCentral Core Disease+5 more
Boston Children's Hospital4,000 enrolled1 locationNCT00272883
Recruiting

Adherence to Home-Based Exercises in Musculoskeletal Disorders

Musculoskeletal DiseaseExercise TrainingStroke+6 more
Konya Beyhekim Training and Research Hospital252 enrolled1 locationNCT07261553