Synovial Sarcoma Clinical Trials

19 recruitingLast updated: June 17, 2026

There are 19 actively recruiting synovial sarcoma clinical trials across 8 countries. Studies span Phase 1, Phase 2, Phase 3, Early Phase 1. Top locations include Houston, Texas, United States, Philadelphia, Pennsylvania, United States, Boston, Massachusetts, United States. Updated daily from ClinicalTrials.gov.


Synovial Sarcoma Trials at a Glance

19 actively recruiting trials for synovial sarcoma are listed on ClinicalTrialsFinder across 6 cities in 8 countries. The largest study group is Phase 1 with 11 trials, with the heaviest enrollment activity in Houston, Philadelphia, and Boston. Lead sponsors running synovial sarcoma studies include Oslo University Hospital, Children's Hospital of Philadelphia, and Baylor College of Medicine.

Browse synovial sarcoma trials by phase

Treatments under study

About Synovial Sarcoma Clinical Trials

Looking for clinical trials for Synovial Sarcoma? There are currently 12 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Synovial Sarcoma trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Synovial Sarcoma clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 119 of 19 trials

Recruiting
Early Phase 1

N-803 in Patients With Progressive Synovial Sarcoma and Myxoid/Round Cell Liposarcoma Previously Treated With Adoptive Cellular Therapy

Synovial SarcomaMyxoid LiposarcomaRound Cell Liposarcoma
Seth Pollack8 enrolled1 locationNCT07261657
Recruiting

Synovial Sarcoma Registry / Biospecimen Repository

Synovial Sarcoma
Children's Hospital of Philadelphia1,000 enrolled1 locationNCT05910307
Recruiting
Phase 1Phase 2

Study in Children and Adolescents of 177Lu-DOTATATE (Lutathera®) Combined With the PARP Inhibitor Olaparib for the Treatment of Recurrent or Relapsed Solid Tumours Expressing Somatostatin Receptor (SSTR) (LuPARPed).

ParagangliomaPheochromocytomaSolid Tumor Cancer+19 more
Fundación de investigación HM25 enrolled1 locationNCT06607692
Recruiting
Phase 1

A Study to Test the Safety, Tolerability and Effect of ZI-MA4-1 for Patients With Locally Advanced or Metastatic Solid Malignancies

Ovarian CancerHead and Neck CancerSynovial Sarcomas+1 more
Zelluna Immunotherapy AS9 enrolled2 locationsNCT07613723
Recruiting
Phase 1

Testing Low-Dose Common Chemotherapy (Liposomal Doxorubicin) in Combination With an Anti-Cancer Drug, Peposertib, in Advanced Sarcoma

Metastatic SarcomaMetastatic LeiomyosarcomaUnresectable Leiomyosarcoma+9 more
National Cancer Institute (NCI)30 enrolled16 locationsNCT05711615
Recruiting
Phase 1

START: Safety and Anti-Tumor Activity of PeptiCRAd-1 in Treatment of Cancer

Triple-Negative Breast CancerColorectal, CancerSarcoma+5 more
Valo Therapeutics Oy15 enrolled7 locationsNCT05492682
Recruiting
Phase 1Phase 2

Personalized Vaccination in Fusion+ Sarcoma Patients (PerVision)

Ewing SarcomaRhabdomyosarcomaSynovial Sarcoma
University Hospital Tuebingen30 enrolled4 locationsNCT06094101
Recruiting
Phase 1

Phase I/Ib Study of NK Expressing an Affinity-enhanced T-cell Receptor (TCR) Against the NY-ESO-1

Synovial SarcomaMyxoid/Round Cell Liposarcoma
M.D. Anderson Cancer Center44 enrolled1 locationNCT06083883
Recruiting
Phase 1Phase 2

Alpha/Beta T and B Cell Depletion With Zoledronic Acid for Solid Tumors

OsteosarcomaEwing SarcomaNeuroblastoma+10 more
University of Florida27 enrolled1 locationNCT06625190
Recruiting
Phase 3

Phase III Trial of Anlotinib, Catequentinib in Advanced Alveolar Soft Part Sarcoma, Leiomyosarcoma, Synovial Sarcoma (APROMISS)

Soft Tissue SarcomaLeiomyosarcomaSynovial Sarcoma+1 more
Advenchen Laboratories, LLC325 enrolled24 locationsNCT03016819
Recruiting
Phase 3

Multi-center Study of TBI-1301 (INN: Mipetresgene Autoleucel; Mip-cel) in Patients With NY-ESO-1 Positive Synovial Sarcoma

Synovial Sarcomas
Takara Bio Inc.5 enrolled2 locationsNCT07174427
Recruiting
Phase 1Phase 2

SPEARHEAD-3 Pediatric Study

OsteosarcomaSynovial SarcomaMalignant Peripheral Nerve Sheath Tumor (MPNST)+1 more
USWM CT, LLC20 enrolled10 locationsNCT05642455
Recruiting
Phase 2

Dose-escalated, Hypofractionated, Definitive Proton Radiotherapy for Patients With Inoperable Soft Tissue Sarcoma.

Soft Tissue Sarcoma (STS)Soft Tissue Sarcoma AdultSynovial Sarcomas+7 more
Oslo University Hospital40 enrolled2 locationsNCT07173972
Recruiting
Phase 2

Hypofractionated, 3-week, Preoperative Proton or X-ray Radiotherapy for Patients With Localized Soft Tissue Sarcoma

Soft Tissue Sarcoma AdultLeiomyosarcomaSynovial Sarcomas+6 more
Oslo University Hospital110 enrolled4 locationsNCT07169344
Recruiting
Phase 1

HER2 Chimeric Antigen Receptor (CAR) T Cells in Combination With Checkpoint Blockade in Patients With Advanced Sarcoma

Soft Tissue SarcomaSarcomaOsteosarcoma+5 more
Baylor College of Medicine25 enrolled1 locationNCT04995003
Recruiting
Phase 1

ACTengine® IMA203 Combined With mRNA-4203

Cutaneous MelanomaSynovial Sarcoma
Immatics US, Inc.15 enrolled4 locationsNCT06946225
Recruiting
Phase 1

AOH1996 for the Treatment of Refractory Solid Tumors

Pancreatic CancerOvarian CancerNon-small Cell Lung Cancer+4 more
City of Hope Medical Center92 enrolled2 locationsNCT05227326
Recruiting
Phase 2

MASCT-I Combined With Doxorubicin and Ifosfamide for First-line Treatment of Advanced Soft Tissue Sarcoma

AngiosarcomaLeiomyosarcomaSynovial Sarcoma+8 more
HRYZ Biotech Co.148 enrolled1 locationNCT06277154
Recruiting
Phase 2

Pasireotide as Maintenance Treatment in Synovial Sarcoma and Desmoplastic Small Round Cell Tumor

Synovial SarcomaDesmoplastic Small Round Cell Tumor
University Hospital Heidelberg28 enrolled4 locationsNCT06456359