Tobacco Clinical Trials

141 recruitingLast updated: June 18, 2026

There are 141 actively recruiting tobacco clinical trials across 33 countries. Studies span Not Applicable, Phase 4, Phase 2, Phase 1, Phase 3, Early Phase 1. Top locations include San Francisco, California, United States, Philadelphia, Pennsylvania, United States, Columbus, Ohio, United States. Updated daily from ClinicalTrials.gov.


Tobacco Trials at a Glance

141 actively recruiting trials for tobacco are listed on ClinicalTrialsFinder across 6 cities in 33 countries. The largest study group is Not Applicable with 89 trials, with the heaviest enrollment activity in San Francisco, Philadelphia, and Columbus. Lead sponsors running tobacco studies include University of California, San Francisco, Ohio State University Comprehensive Cancer Center, and Johns Hopkins University.

Treatments under study

About Tobacco Clinical Trials

Looking for clinical trials for Tobacco? There are currently 4 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Tobacco trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Tobacco clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 141 trials

Recruiting
Not Applicable

Symptoms and Functions in Patients With COPD and Chronic Bronchitis Switching From CIG to THS

COPDSmokingTobacco Use
Philip Morris Products S.A.290 enrolled112 locationsNCT07108166
Recruiting
Not Applicable

Comparative Effectiveness of Mobile Health Smoking Cessation Approaches Among Underserved Patients in Primary Care

Tobacco Use Cessation
University of Florida1,332 enrolled1 locationNCT05415761
Recruiting
Phase 4

E-cigarette Cessation in Adults Who Co-use Cannabis

Tobacco Use DisorderNicotine Dependence
Medical University of South Carolina105 enrolled3 locationsNCT06688539
Recruiting
Not Applicable

Catalyzing Cigarette Smoking Cessation Through Harm Reduction Sampling Among People Unmotivated to Quit

Tobacco UseCigarette SmokingCigarette Smoking Behavior
Abramson Cancer Center at Penn Medicine472 enrolled1 locationNCT07199517
Recruiting
Not Applicable

Young Adult Tobacco/Nicotine and Cannabis Co-use

Tobacco Use DisorderNicotine Dependence
Medical University of South Carolina350 enrolled1 locationNCT06239350
Recruiting
Not Applicable

Integrating CHWs Into Prenatal Care for Maternal Smoking Cessation

Tobacco Use CessationTobacco UseTobacco Use in Childbirth
Loma Linda University105 enrolled2 locationsNCT06438549
Recruiting
Phase 2

Neural Mechanisms Connecting Deficient Sleep and Smoking Relapse

InsomniaTobacco UseTobacco Cessation
Yale University114 enrolled2 locationsNCT06609369
Recruiting
Not Applicable

Impact of Behavior Modification Interventions and Lung Cancer Screening on Smoking Cessation in People Living With HIV: A Feasibility Study

HIV InfectionTobacco-Related Carcinoma
AIDS Malignancy Consortium100 enrolled11 locationsNCT04949464
Recruiting
Not Applicable

A Novel Mobile Health Intervention for Improving Tobacco Cessation Among Young Adults

Tobacco-Related Carcinoma
Fred Hutchinson Cancer Center140 enrolled2 locationsNCT07571018
Recruiting
Not Applicable

Effect of Yoga on Reducing Craving in Tobacco Dependent Individuals

Tobacco Dependence
University of Pittsburgh96 enrolled1 locationNCT06488443
Recruiting
Not Applicable

Healthy Family Project: Tobacco Use and Smoke Exposure in Asian American Communities

Smoking CessationTobacco-Related Carcinoma
University of California, San Francisco760 enrolled1 locationNCT07049757
Recruiting

Lung Macrophage Populations and Functions in Chronic Obstructive Pulmonary Disease (COPD)-Susceptible Smokers

COPDSmokingTobacco Use
University of California, San Francisco40 enrolled3 locationsNCT04722835
Recruiting
Not Applicable

A Study to Determine the Effects of ENDS Flavor Availability on Abstinence Within Smokers

SmokingTobacco
RAI Services Company1,280 enrolled7 locationsNCT07598136
Recruiting
Not Applicable

Support and Outreach to Increase Screening for Lung Cancer in Patients With a History of Smoking

Lung CarcinomaTobacco-Related Carcinoma
Ronald Myers822 enrolled1 locationNCT05679349
Recruiting
Not Applicable

Influence of Authorized Smokeless Tobacco Product Modified Risk Claims II: Laboratory Assessment of Sensory and Subjective Effects

Smokeless Tobacco
Roswell Park Cancer Institute50 enrolled1 locationNCT07107139
Recruiting
Not Applicable

A Digital Intervention (ACT on Vaping App) for Vaping Cessation in Young Adult E-Cigarette Users

Tobacco-Related CarcinomaNicotine Dependence
Fred Hutchinson Cancer Center1,178 enrolled1 locationNCT06909500
Recruiting

The Efficacy of Conventional Screening Versus mHealth Screening in Early Detection of Oral Potentially Malignant Disorders and Oral Cancer Amongst the Rural Population of Varanasi: A Prospective and Blinded Study

SmokingSmoking, TobaccoSmoking, Cigarette+5 more
Memorial Sloan Kettering Cancer Center5,122 enrolled1 locationNCT06535867
Recruiting
Not Applicable

Pilot Study of Communication for Dual Users of Cigarettes and E-cigarettes

Tobacco ProductsCigarettesElectronic Cigarettes
UNC Lineberger Comprehensive Cancer Center90 enrolled1 locationNCT07599462
Recruiting
Not Applicable

Developing a Scalable Tobacco Cessation Program for Cancer Survivors and Caregivers

Tobacco UseNicotine Use
University of Florida204 enrolled1 locationNCT06851936
Recruiting

Measuring Communal Coping in Dual-smoking Couples Making a Quit Attempt

Quitting smokingSmoking CessationSmoking, Cigarette+3 more
University of Colorado, Denver250 enrolled1 locationNCT07553962