Little Cigar Oxidants
Oxidative Stress and Harmful Constituent Levels Associated With Little Cigars
Milton S. Hershey Medical Center
50 participants
Mar 23, 2026
INTERVENTIONAL
Conditions
Summary
Determine the effects of little cigars on human exposure to tobacco smoke oxidants. In a balanced randomized cross-over study design in cigarette smokers, subjects will be assigned to 3 exposure groups. These include a high oxidant little cigar exposure condition, a low oxidant little cigar exposure condition, and their usual cigarette. Biological samples will be collected before and after product usage.
Eligibility
Inclusion Criteria8
- Aged 21 - 65 years old
- Daily cigarette smoker (>= 1 cigarette per day);
- Smoke regular, filtered cigarettes or machine rolled cigarettes with a filter
- No current or past use of Little Cigars
- All other forms of nicotine must be used <6 days out of the past 30 days.
- Able to read and write in English
- No serious cigarette smoking quit attempt or use of any FDA-approved smoking cessation medication in the prior 30 days
- No plan to quitting smoking in the next 3 months
Exclusion Criteria5
- Women who are pregnant and/or nursing or trying to become pregnant
- Unstable or significant medical condition in the past 3 months (e.g., recent heart attack or other serious heart condition, stroke, severe angina)
- Respiratory diseases (e.g., exacerbations of asthma or Chronic Obstructive Pulmonary Disease (COPD), require oxygen, require oral prednisone), kidney (e.g., dialysis) or liver disease (e.g., cirrhosis), severe immune system disorders (e.g., uncontrolled HIV/AIDS, multiple sclerosis symptoms) or any medical disorder/medication that may affect participant safety or biomarker data
- Uncontrolled substance abuse or inpatient treatment for that condition in the past 6 months
- Exhaled Carbon Monoxide (CO) measurement of >= 17 parts per million
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Interventions
Subjects will be given a high oxidant little cigar to use for outcome measure data collection in the lab before and after product usage.
Subjects will be given a low oxidant little cigar to use for outcome measure data collection in the lab before and after product usage.
Subjects will use their own cigarette for outcome measure data collection in the lab before and after product usage.
Locations(1)
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NCT06310187