Phase 1 Transplantation Clinical Trials
30 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 30 trials
Recruiting
Phase 1
Eight-Treg Study:Trial of Adoptive Immunotherapy With Autologous ex Vivo Expanded Regulatory CD8+ T Cells in Living Donor Kidney Transplant Recipients
Kidney Transplantation
Nantes University Hospital9 enrolled1 locationNCT06777719
Recruiting
Phase 1Phase 2
The Lowest Effective Dose of Post-Transplantation Cyclophosphamide in Combination With Sirolimus and Mycophenolate Mofetil as Graft-Versus-Host Disease Prophylaxis After Reduced Intensity Conditioning and Peripheral Blood Stem Cell Transplantation
Hematopoietic Stem Cell TransplantationPeripheral Blood Stem Cell Transplantation
National Cancer Institute (NCI)260 enrolled2 locationsNCT05436418
Recruiting
Phase 1
Alzheimer's Disease and Faecal Microbiota Transplantation -a Pilot Study
Alzheimer s DiseaseFaecal Microbiota Transplantation (FMT)
University Hospital of North Norway10 enrolled1 locationNCT07332260
Recruiting
Phase 1
CD45RA-depleted CD19-CAR T Cell Consolidation After TCRαβ+/CD19 B Cell-depleted Haploidentical Hematopoietic Cell Transplantation for Relapsed/Refractory CD19+ ALL and Lymphoma
Hematologic MalignancyRelapsed Pediatric ALLHematopoietic Cell Transplantation
St. Jude Children's Research Hospital60 enrolled1 locationNCT07257419
Recruiting
Phase 1
Reduced Intensity Allogeneic HCT in Advanced Hematologic Malignancies w/T-Cell Depleted Graft
Acute LeukemiaMyelodysplastic SyndromesMyeloproliferative Disorders+3 more
Stanford University77 enrolled1 locationNCT05088356
Recruiting
Phase 1
Momelotinib During and After HCT in Myelofibrosis
MyelofibrosisHematopoietic Cell Transplantation (HCT)
Massachusetts General Hospital28 enrolled1 locationNCT07104799
Recruiting
Phase 1
Using T-Cell Alloreactivity and Chimerism to Guide Immunosuppression Minimization in Intestinal Transplantation
Intestinal Transplantation
Columbia University6 enrolled1 locationNCT04804891
Recruiting
Phase 1Phase 2
Study to Evaluate the Safety and Efficacy of the 10 GE Xenokidney in Patients With ESRD
Kidney TransplantationXenotransplantationESRD (End-Stage Renal Disease)
United Therapeutics50 enrolled2 locationsNCT06878560
Recruiting
Phase 1Phase 2
Immune Tolerance Induction After Liver Transplantation
Liver TransplantationEnd Stage Liver DiseaseImmune Tolerance+6 more
University of California, Los Angeles12 enrolled1 locationNCT07269041
Recruiting
Phase 1Phase 2
A Study to Investigate Safety and Effectiveness of Porcine Pancreatic Cells (OPF-310) in Patients With Type 1 Diabetes Mellitus
Metabolic DiseaseDiabetes Mellitus, Type 1Type 1 Diabetes+14 more
Otsuka Pharmaceutical Factory, Inc.13 enrolled1 locationNCT06575426
Recruiting
Phase 1
Adoptive T Lymphocyte Administration for Chronic Norovirus Treatment in Immunocompromised Hosts
Viral InfectionHematopoietic Stem Cell Transplantation (HSCT)Primary Immunodeficiency Disorders (PID)
Children's National Research Institute48 enrolled3 locationsNCT04691622
Recruiting
Phase 1
Zoledronate to Prevent Bone Health Complications in Pediatric Hematopoietic Stem Cell Transplant Survivors
Hematopoietic Stem Cell Transplantation
Children's Hospital Medical Center, Cincinnati20 enrolled1 locationNCT07375290
Recruiting
Phase 1
A Real-World Study of Fecal Transplants for Cancer Therapy Side Effects
Antineoplastic AgentsGastrointestinal NeoplasmsFecal Microbiota Transplantation (FMT)
Second Affiliated Hospital, School of Medicine, Zhejiang University90 enrolled1 locationNCT07319364
Recruiting
Phase 1Phase 2
The Effects of Vonoprazan Fumarate on DGF Incidence in DD Kidney Transplant Recipients
Kidney TransplantationDelayed Graft Function
First Affiliated Hospital of Chongqing Medical University47 enrolled2 locationsNCT07275632
Recruiting
Phase 1
Effect of Moderate Renal Impairment and Race/Ethnicity on Treosulfan Pharmacokinetics
Myelodysplastic Syndrome (MDS)Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)Acute Myeloid Leukaemia (AML)
medac GmbH36 enrolled4 locationsNCT05534620
Recruiting
Phase 1Phase 2
Study to Evaluate the Safety and Efficacy of the GGTA1 KO Thymokidney in Patients With ESRD
Kidney TransplantationXenotransplantationESRD (End-Stage Renal Disease)
United Therapeutics50 enrolled1 locationNCT07224763
Recruiting
Phase 1
Safety and Early Efficacy of iPSC-Derived Motor Neuron Progenitor Cells (XS228) in Subacute Spinal Cord Injury: A Phase I Trial
EfficacySafetySpinal Cord Injury+4 more
XellSmart Bio-Pharmaceutical (Suzhou) Co., Ltd.12 enrolled1 locationNCT06976229
Recruiting
Phase 1
Remimazolam Infusion in Kidney Transplant Patients: A Multicenter Study
Chronic Kidney DiseasesRenal Transplantation
Qianfoshan Hospital30 enrolled1 locationNCT07045467
Recruiting
Phase 1Phase 2
Microbial Restoration in Inflammatory Bowel Diseases
Inflammatory Bowel DiseasesCrohn DiseaseMicrobiome+1 more
St Vincent's Hospital Melbourne120 enrolled1 locationNCT04970446
Recruiting
Phase 1
Prophylactic CD45RA-depleted DLI After Haploidentical Transplantation/RIC
Hematologic MalignancyHaplo-identical Stem Cell Transplantation
University Hospital, Geneva12 enrolled1 locationNCT05066412