Phase 1 Tumors Clinical Trials
531 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 531 trials
Recruiting
Phase 1Phase 2
Study of mRNA-4359 Administered Alone and in Combination With Immune Checkpoint Blockade in Participants With Advanced Solid Tumors
Advanced Solid Tumors
ModernaTX, Inc.361 enrolled31 locationsNCT05533697
Recruiting
Phase 1Phase 2
Novel Indenoisoquinolone CMYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent Glioblastoma
Brain CancerGBMGlioma+12 more
National Institute of Neurological Disorders and Stroke (NINDS)40 enrolled1 locationNCT07416188
Recruiting
Phase 1
Phase 1a/b Study of ZL-6201 Safety, PK, and Preliminary Efficacy in Sarcoma and Selected Tumors
Solid TumorsSarcomas
Zai Lab (Shanghai) Co., Ltd.180 enrolled5 locationsNCT07374848
Recruiting
Phase 1
Study of GS-0201 Alone and in Combination in Participants With Advanced Solid Tumors
Advanced Solid Tumors
Gilead Sciences278 enrolled7 locationsNCT06167317
Recruiting
Phase 1
A Study of BL-ARC002 in Patients With Locally Advanced or Metastatic Solid Tumors
Solid Tumors
Sichuan Baili Pharmaceutical Co., Ltd.22 enrolled1 locationNCT07591155
Recruiting
Phase 1Phase 2
Study of GVV858 as a Single Agent or in Combination With Endocrine Therapy in Patients With HR+/HER2- Breast Cancer and Other Advanced Solid Tumors
Advanced HR+/HER2- Breast CancerAdvanced CCNE1-amplified Solid TumorsMetastatic Castration-resistant Prostate Cancer
Novartis Pharmaceuticals205 enrolled8 locationsNCT07288359
Recruiting
Phase 1Phase 2
CR-001 in Adult Participants With Locally Advanced or Metastatic Solid Tumors
Locally Advanced/Metastatic Solid Tumors
Crescent Biopharma, Inc.290 enrolled12 locationsNCT07335497
Recruiting
Phase 1Phase 2
A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements
Metastatic Solid TumorsLocally Advanced Solid Tumors
Turning Point Therapeutics, Inc.500 enrolled165 locationsNCT03093116
Recruiting
Phase 1Phase 2
A Phase I/II of HRS-6719 in Patients With Advanced/Metastatic Solid Tumors
Advanced/Metastatic Solid Tumors
Shandong Suncadia Medicine Co., Ltd.120 enrolled2 locationsNCT06922357
Recruiting
Phase 1
A Phase I Clinical Study of HLX316 in Participants With Advanced/Metastatic Solid Tumors
Advanced/Metastatic Solid Tumors
Shanghai Henlius Biotech41 enrolled5 locationsNCT07541534
Recruiting
Phase 1
A Clinical Study of KK2260 in Patients With Advanced or Metastatic Solid Tumors
Advanced or Metastatic Solid Tumors
Kyowa Kirin Co., Ltd.189 enrolled14 locationsNCT06248411
Recruiting
Phase 1Phase 2
BC3195 in Combination With Pembrolizumab in Participants With Locally Advanced or Metastatic Solid Tumors
Locally Advanced or Metastatic Solid Tumors
Biocity Biopharmaceutics Co., Ltd.111 enrolled1 locationNCT07469774
Recruiting
Phase 1Phase 2
A Phase Ⅰ/Ⅱa Study of HMPL-A251 in Participants With Advanced or Metastatic HER2-expressing Solid Tumors
Solid Tumors, Adult
Hutchmed147 enrolled16 locationsNCT07228247
Recruiting
Phase 1
Controlled Cold Exposure Combined With PD-1/PD-L1 Immunotherapy in Solid Tumors (NIVALIS)
Solid TumorsImmunotherapyCold Exposure+1 more
West China Hospital24 enrolled1 locationNCT07538479
Recruiting
Phase 1
GenSci145 as Monotherapy or in Combination Therapy, in Participants With PIK3CA-mutated, Locally Advanced or Metastatic Solid Tumors.
Locally Advanced or Metastatic Solid Tumors With PIK3CA-mutated
Changchun GeneScience Pharmaceutical Co., Ltd.186 enrolled1 locationNCT07407504
Recruiting
Phase 1
A First-in-Human Study of BG-C0902 Alone and in Combination With Other Therapeutic Agents in Patients With Advanced Solid Tumors
Advanced Solid TumorSolid Tumors
BeOne Medicines63 enrolled14 locationsNCT07181681
Recruiting
Phase 1
A Study of BG-C477 in Participants With Advanced Solid Tumors
Advanced Solid Tumors
BeOne Medicines310 enrolled49 locationsNCT06596473
Recruiting
Phase 1
Preoperative Imatinib and Fampridine in KIT Mutant Gastrointestinal Stromal Tumor
Gastrointestinal Stromal Tumors
University of California, San Diego18 enrolled1 locationNCT07171203
Recruiting
Phase 1Phase 2
First in Human Study of TUB-030 in Patients With Advanced Solid Tumors
TNBC - Triple-Negative Breast CancerAdvanced Solid TumorsNSCLC+3 more
Tubulis GmbH250 enrolled16 locationsNCT06657222
Recruiting
Phase 1
5-aza-4'-Thio-2'-Deoxycytidine (Aza-TdC) in People With Advanced Solid Tumors
Solid TumorsNeoplasms
National Cancer Institute (NCI)65 enrolled1 locationNCT03366116