Phase 1 Tumors Clinical Trials
555 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 555 trials
Recruiting
Phase 1
Metarrestin (ML-246) in Subjects With Metastatic Solid Tumors
Advanced Breast CancerAdvanced Solid TumorsMetastatic Pancreatic Cancer+3 more
National Cancer Institute (NCI)116 enrolled2 locationsNCT04222413
Recruiting
Phase 1Phase 2
Personalized Neoantigen Peptide Vaccines for Solid Tumors
Solid TumorsAdvanced CancerRecurrent Cancer+2 more
Seqker Biosciences, Inc.10 enrolled1 locationNCT07002203
Recruiting
Phase 1
First-in-Human Study of ADCE-B05 in Patients With Advanced Solid Tumors
Solid Tumors (Phase 1)
Adcendo ApS180 enrolled7 locationsNCT07362888
Recruiting
Phase 1Phase 2
A Study of SHR-4610 Injection in Patients With Advanced Solid Tumors
Solid Tumors
Shanghai Shengdi Pharmaceutical Co., Ltd258 enrolled1 locationNCT07231211
Recruiting
Phase 1
A Study in Patients With Metastatic Castration-Resistant Prostate Cancer
Metastatic Castration-resistant Prostate CancermCRPC (Metastatic Castration-resistant Prostate Cancer)Prostatic Neoplasms, Castration-Resistant+5 more
Flare Therapeutics Inc.60 enrolled10 locationsNCT07719361
Recruiting
Phase 1
Study Evaluating ISM8207 in Participants With Advanced Solid Tumors and Relapsed/Refractory B-Cell Lymphoma
Advanced Solid TumorsRelapsed/Refractory B-cell Lymphoma
InSilico Medicine Hong Kong Limited60 enrolled4 locationsNCT06445517
Recruiting
Phase 1Phase 2
An Open, Single-center Clinical Study of Surufatinib Combined With Temozolomide and S-1 in the First-line Treatment of Advanced Neuroendocrine Tumors
Neuroendocrine Tumors
Cancer Institute and Hospital, Chinese Academy of Medical Sciences40 enrolled1 locationNCT06038461
Recruiting
Phase 1
A Study of MRG007 (ARR-217) in Patients With Advanced Solid Tumors
Colorectal, CancerPancreatic CancerGastric Cancer+1 more
ArriVent BioPharma, Inc.405 enrolled20 locationsNCT07066657
Recruiting
Phase 1Phase 2
Safety and Efficacy of Ponatinib for Treatment of Pediatric Recurrent or Refractory Leukemias, Lymphomas or Solid Tumors
Solid TumorsAcute Lymphoblastic LeukemiaAcute Myeloid Leukemia+6 more
Incyte Biosciences International Sàrl70 enrolled23 locationsNCT03934372
Recruiting
Phase 1
IDOV-Immune for Advanced Solid Tumors
Breast CancerColorectal, CancerEsophageal Cancer+13 more
ViroMissile, Inc.78 enrolled5 locationsNCT06910657
Recruiting
Phase 1
A Study of ASP1002 in Adults for Treatment of Solid Tumors
Advanced Solid Tumors
Astellas Pharma Global Development, Inc.798 enrolled15 locationsNCT05719558
Recruiting
Phase 1Phase 2
A Study to Evaluate Claudin 18.2-Directed ADC LCB02A in Advanced Solid Tumors
Advanced Solid Tumors
LigaChem Biosciences, Inc.191 enrolled8 locationsNCT07460375
Recruiting
Phase 1
A Study to Evaluate the Safety of INCA33890 in Participants With Advanced or Metastatic Solid Tumors
Solid TumorsAdvanced Solid TumorsMetastatic Solid Tumors
Incyte Corporation570 enrolled39 locationsNCT05836324
Recruiting
Phase 1
A Study to Evaluate the Safety, Pharmacokinetics, and Anti-Tumor Activity of VVD-133214 as Monotherapy and in Combination in Participants With Advanced Solid Tumors
Colorectal, CancerAdvanced Solid Tumors
Vividion Therapeutics, Inc.280 enrolled38 locationsNCT06004245
Recruiting
Phase 1
A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors
Esophageal CancerPancreatic CancerUrothelial Carcinoma+10 more
Pfizer310 enrolled30 locationsNCT07090499
Recruiting
Phase 1Phase 2
PEEL-224, Vincristine and Temozolomide in Pediatric Solid Tumors
Refractory NeuroblastomaRefractory RhabdomyosarcomaRefractory Solid Tumors+3 more
Theodore Laetsch59 enrolled7 locationsNCT06721689
Recruiting
Phase 1
Phase 1a/b Study of ZL-6201 Safety, PK, and Preliminary Efficacy in Sarcoma and Selected Tumors
Solid TumorsSarcomas
Zai Lab (Shanghai) Co., Ltd.180 enrolled8 locationsNCT07374848
Recruiting
Phase 1
A Clinical Trial to Evaluate the Safety, Tolerability and Clinical Efficacy of M3T01 Monotherapy and in Combination With Pembrolizumab and Other Systemic Therapies
Advanced Solid Tumors
Providence Health & Services110 enrolled1 locationNCT06719362
Recruiting
Phase 1
To Evaluate the Safety, Tolerability, Pharmacokinetics and Antitumor Activity of DAY301 in Participants With Locally Advanced or Metastatic Solid Tumors
Advanced or Metastatic Solid Tumors
Day One Biopharmaceuticals, Inc.300 enrolled11 locationsNCT06752681
Recruiting
Phase 1Phase 2
A Study of ZL-1310 in Participants With Selected Solid Tumors
Solid Tumors
Zai Lab (Shanghai) Co., Ltd.166 enrolled23 locationsNCT06885281