Phase 3 Urothelial Carcinoma Clinical Trials
18 recruitingPhase 3
What is a Phase 3 trial?
Phase 3 trials compare the new treatment against the current standard of care in large groups, often hundreds to thousands of participants. Successful Phase 3 results are typically required for regulatory approval.
Showing 1–18 of 18 trials
Recruiting
Phase 2Phase 3
Testing the Addition of MEDI4736 (Durvalumab) to Chemotherapy Before Surgery for Patients With High-Grade Upper Urinary Tract Cancer
Renal Pelvis and Ureter Urothelial Carcinoma
National Cancer Institute (NCI)131 enrolled258 locationsNCT04628767
Recruiting
Phase 3
A Study Comparing the Combination of Pembrolizumab and Sacituzumab Govitean-hziy Versus Standard of Care in the Treatment of Advanced Urothelial Cancer
Locally Advanced Urothelial CarcinomaMetastatic Urothelial CarcinomaUnresectable Urothelial Carcinoma
National Cancer Institute (NCI)320 enrolled150 locationsNCT06524544
Recruiting
Phase 2Phase 3
Testing the Role of DNA Released From Tumor Cells Into the Blood in Guiding the Use of Immunotherapy After Surgical Removal of the Bladder, Kidney, Ureter, and Urethra for Urothelial Cancer Treatment, MODERN Study
Muscle Invasive Bladder Urothelial CarcinomaStage IV Bladder Urothelial Carcinoma AJCC v7Muscle Invasive Renal Pelvis Urothelial Carcinoma+4 more
National Cancer Institute (NCI)992 enrolled499 locationsNCT05987241
Recruiting
Phase 3
A Phase 3 Single-arm Study of UGN-104 for the Treatment of Low-grade Upper Tract Urothelial Cancer
Urothelial CarcinomaUpper Urinary Tract Urothelial Carcinoma
UroGen Pharma Ltd.70 enrolled62 locationsNCT06774131
Recruiting
Phase 3
Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients Receiving the Usual Chemotherapy Treatment for Bladder Cancer, ARCHER Study
Muscle Invasive Bladder Urothelial CarcinomaStage II Bladder Cancer AJCC v8Stage IIIA Bladder Cancer AJCC v8
NRG Oncology486 enrolled211 locationsNCT07097142
Recruiting
Phase 3
A Study Comparing BL-B01D1 With Chemotherapy of Physician's Choice in Patients With Recurrent or Metastatic Urothelial Carcinoma(PANKU-Bladder01)
Urothelial Carcinoma
Sichuan Baili Pharmaceutical Co., Ltd.508 enrolled1 locationNCT06857175
Recruiting
Phase 3
Study of Tislelizumab in Combination With Chemotherapy Compared to Chemotherapy Alone for Participants With Urothelial Carcinoma
Urothelial Carcinoma
BeiGene420 enrolled46 locationsNCT03967977
Recruiting
Phase 3
Evaluating Safety and Efficacy of Verity-BCG in BCG-naïve Patients With Intermediate and High-risk Non-muscle Invasive Bladder (NMIBC)
Bladder CancerUrothelial Carcinoma BladderNeoplasm Recurrence+3 more
Verity Pharmaceuticals Inc.540 enrolled6 locationsNCT05037279
Recruiting
Phase 3
A Trial of SHR-A2102 With Adebrelimab in Locally Advanced or Metastatic Urothelial Carcinoma
Locally Advanced or Metastatic Urothelial Carcinoma
Suzhou Suncadia Biopharmaceuticals Co., Ltd.462 enrolled1 locationNCT07393542
Recruiting
Phase 2Phase 3
Multicenter Clinical Trial of ST-02 for Ablation of Upper Tract Urothelial Carcinoma
Urothelial Carcinoma of the Renal Pelvis and UreterTransitional Cell Cancer of the Renal Pelvis and Ureter
University of British Columbia70 enrolled4 locationsNCT06124976
Recruiting
Phase 3
Neoadjuvant Upper Tract Invasive Cancer Trial (NAUTICAL)
Bladder CancerBladder Urothelial Carcinoma
University Health Network, Toronto14 enrolled2 locationsNCT04574960
Recruiting
Phase 3
A Phase III Study of SHR-A2102 Versus Investigator-selected Therapy in Advanced Urothelial Carcinoma
Advanced Urothelial Carcinoma
Shanghai Hengrui Pharmaceutical Co., Ltd.402 enrolled1 locationNCT06738251
Recruiting
Phase 3
Gemcitabine Versus Water Irrigation in Upper Tract Urothelial Carcinoma
Urothelial Cancer of Renal PelvisUrothelial Carcinoma Ureter
University of Texas Southwestern Medical Center132 enrolled1 locationNCT04865939
Recruiting
Phase 3
Study Comparing the Standard Administration of IO Versus the Same IO Administered Each 3 Months in Patients in Response After 6 Months of Standard IO
Triple-Negative Breast CancerCervical CancerUrothelial Carcinoma+12 more
UNICANCER646 enrolled40 locationsNCT05078047
Recruiting
Phase 3
A Study to Evaluate 9MW2821 Versus Chemotherapy in Subjects With Previously Treated Locally Advanced or Metastatic Urothelial Cancer
Advanced Urothelial Carcinoma
Mabwell (Shanghai) Bioscience Co., Ltd.432 enrolled1 locationNCT06196736
Recruiting
Phase 2Phase 3
Modular Trial of sEphB4-HSA in EphrinB2-High Solid Tumors
Metastatic Urothelial CarcinomaMuscle-Invasive Bladder Carcinoma
Vasgene Therapeutics, Inc700 enrolled1 locationNCT06493552
Recruiting
Phase 3
9MW2821 in Combination With Toripalimab vs Standard Chemotherapy in Locally Advanced or Metastatic Urothelial Cancer
Urothelial Carcinoma
Mabwell (Shanghai) Bioscience Co., Ltd.460 enrolled1 locationNCT06592326
Recruiting
Phase 3
A Study of RC48-ADC Combined With Toripalimab For First-line Treatment of Urothelial Carcinoma
Urothelial CarcinomaHER2-expressing
RemeGen Co., Ltd.452 enrolled2 locationsNCT05302284