Phase 1 Uveal Melanoma Clinical Trials
11 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–11 of 11 trials
Recruiting
Phase 1
Tebentafusp and Roginolisib in Uveal Melanoma to Prolong T-cell Homeostasis
Uveal Melanoma, Metastatic
St Vincent's Hospital, Sydney8 enrolled2 locationsNCT07203391
Recruiting
Phase 1
Intravenous and Intrathecal Nivolumab in Treating Patients With Leptomeningeal Disease
Clinical Stage IV Cutaneous Melanoma AJCC v8Metastatic Lung Non-Small Cell CarcinomaMetastatic Melanoma+7 more
M.D. Anderson Cancer Center75 enrolled1 locationNCT03025256
Recruiting
Phase 1
Gene Modified Immune Cells After Conditioning Regimen for the Treatment of Stage IIIC or IV Melanoma or Metastatic Solid Tumors
Breast CancerHead and Neck Squamous Cell CarcinomaMetastatic Malignant Solid Neoplasm+14 more
Anusha Kalbasi18 enrolled3 locationsNCT04119024
Recruiting
Phase 1
A Phase 1-1b Study to Evaluate the Safety, Efficacy and Dosimetry of Study Drug A9-3408 in Subjects With Metastatic Melanoma
Melanoma MetastaticMucosal MelanomaUveal Melanoma, Metastatic
Alpha-9 Oncology USA Inc.50 enrolled4 locationsNCT07076550
Recruiting
Phase 1
Safety and Preliminary Efficacy of MBS8(1V270) in Cancer Patients With Advanced Solid Tumours
Advanced Solid TumorCutaneous MelanomaUveal Melanoma, Metastatic
MonTa Biosciences ApS106 enrolled5 locationsNCT04855435
Recruiting
Phase 1
A Study of LN-144 or LN-145 in People With Advanced Uveal Melanoma, Undifferentiated Pleomorphic Sarcoma, or Dedifferentiated Liposarcoma
MelanomaMetastatic MelanomaUveal Melanoma+1 more
Memorial Sloan Kettering Cancer Center30 enrolled2 locationsNCT05607095
Recruiting
Phase 1Phase 2
Study of IDE196 in Patients With Solid Tumors Harboring GNAQ/11 Mutations or PRKC Fusions
Cutaneous MelanomaMetastatic Uveal Melanoma
IDEAYA Biosciences336 enrolled15 locationsNCT03947385
Recruiting
Phase 1Phase 2
Tebentafusp-tebn With LDT in Metastatic UM
Metastatic Uveal Melanoma
Thomas Jefferson University109 enrolled1 locationNCT06626516
Recruiting
Phase 1Phase 2
Evaluation of the Safety, Efficacy, and Pharmacokinetics of NBM-BMX in Patients With Metastatic Uveal Melanoma
Metastatic Uveal MelanomaUveal Melanoma, MetastaticUveal Melanoma, Recurrent+2 more
Novelwise Pharmaceutical Corporation36 enrolled3 locationsNCT07136181
Recruiting
Phase 1
Targeted Alpha Particle Radiotherapy for Metastatic Uveal Melanoma
Uveal MelanomaMetastatic
Modulation Therapeutics, Inc.16 enrolled1 locationNCT05496686
Recruiting
Phase 1Phase 2
Adding IL-2 to Tebentafusp to Eradicate Cancer Progression
Uveal MelanomaMetastatic Uveal MelanomaMetastatic Uveal Melanoma in the Liver
St Vincent's Hospital, Sydney8 enrolled2 locationsNCT07063875