CompletedPhase 1ACTRN12607000372482

A Study into High Flow Humidified Nasal Oxygen Therapy (OptiflowTM) and its' Impact on Lung Pressures.

A Study of Cardiac Surgical Patients Using High Flow Humidified Nasal Oxygen Therapy (OptiflowTM) and its' Impact on Mean Airway Pressures at Different Flow Rates.

Sponsor

Fisher and Paykel Healthcare Ltd

Enrollment

15 participants

Start Date

Sep 10, 2007

Study Type

Interventional

Conditions

Acute Respiratory Failure

Summary

This study will describe the relationship between the flow of gas delivered by the OptiflowTM system and the pressure exerted in the upper airways of 15 cardiac surgical patients. The researchers wish to demonstrate that more gas flow will deliver higher pressures to the airways.This information is needed so that doctors can be guided as to how much flow to administer to patients in order to achieve a desired airway pressure. Such pressure in the airways can assist patients who have breating difficulties. This data will also inform future, more detailed research in this area.

Eligibility

Sex: Both males and femalesMin Age: 18 Yearss

Plain Language Summary

Simplified for easier understanding

This study investigates a Study into High Flow Humidified Nasal Oxygen Therapy (OptiflowTM) and its' Impact on Lung Pressures. It is looking for both men and women, aged 18 and older who have the patient is undergoing cardiac surgery requiring sternotomy. If you are interested, you may need to attend study visits and follow the research team's instructions.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

Whilst participants (n15) are still sedated following cardiac surgery, a 10F pressure catheter will be inserted into the hypopharynx via the nose. Once awake and extubated, participants will be commenced on the OptiflowTM system. Once settled on the therapy the pressure catheter position will be confirmed using end tidal CO2 monitoring. Pressure measurements will then be carried out with three different gas flow rates:30, 40 and 50L/min with mouth open and then repeated with mouth closed. The pressure catheter will be gently removed at the end of this period. The measurements will take approximately 30mins to complete. The intervention is OptiflowTM at three different flow rates. We are investigating only the relationship between flow and pressure. We hope to describe a positive and linear relationship between flow and pressure. ie more flow equals more pressure.