Bacille Calmette-Guérin (BCG) Immune Response Study
Improving protection against childhood tuberculosis: the influence of Bacille Calmette-Guérin (BCG) vaccine strain and age on protective immunity
The Mercy Hospital for Women
256 participants
Apr 26, 2008
Interventional
Conditions
Summary
This study is investigating the influence of vaccine strain and age at immunisation on the immune response in children to Bacille Calmette-Guérin (BCG) immunisation. The underlying hypothesis is that there is a measurable difference in the qualtitative and qualitative immune response which may be associated with differences in the level of protection
Eligibility
Inclusion Criteria1
- Term, well newborn infants.
Exclusion Criteria1
- Family history of immunodeficiencies. Mother with HIV. Mother with active TB.
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Interventions
Use of three different BCG vaccine strains (BCG-Denmark, BCG-Japan, BCG-Russia) for immunisation at birth. Immunisation at 2 months of age with one BCG vaccine strain (BCG-Denmark). In all study groups 0.05ml of BCG will be administered intradermally.
Locations(1)
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ACTRN12608000227392