A trial of Plasmalyte vs Bicarbonate based prime in patients undergoing cardiopulmonary bypass
Quantification of the role of acetate and gluconate to the changes in anion gap and strong ion gap caused by Plasmalyte 148 cardiopulmonary bypass pump prime: A comparison with bicarbonate
Princess Alexandra hospital
30 participants
Jan 20, 2009
Interventional
Conditions
Summary
Heart operations is frequently accompanied by a degree of inflammation and irregular heart beat.This study aims to determine if the use of a solution containing bicarbonate during heart operations will reduce the amount of inflammation and improve heart rhythm. During heart bypass surgery, patients' circulation is supported by a heart lung machine. During this process, the patient's blood is mixed with around 2 L of fluid. In Brisbane, we have developed a fluid for use during heart surgery. Initial results suggest that it maintains the acid levels in the blood better than the conventionally used fluid. This project is seeking to determine whether the new fluid also improves the overall well being of the patient. If shown to improve the overall well being of the patient, it has the potential to reduce hospital stay and hospital costs.
Eligibility
Plain Language Summary
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Interventions
Patients undergoing cardiopulmonarybypass will receive a pump prime of 2 litres of bicarbonate based prime . The bicarbonate based prime has the following composition.(Sodium (Na) 140 mmol/L, Chloride (Cl) 116 mmol/L and bicarbonate 24 mmol/L). The pump flow rates and the membrane oxygenator protocls will be as per standard practice.
Locations(1)
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ACTRN12610000267055