The significance of hyperglycaemia in survivors of critical illness and potential mechanisms underlying development of type 2 diabetes

This study is investigating whether people who had high blood sugar during a critical illness (such as intensive care admission) are at greater risk of developing Type 2 diabetes later in life. Researchers will compare survivors of critical illness with high blood sugar against those who had normal blood sugar, and against healthy volunteers, to understand what happens to blood sugar regulation after critical illness. You may be eligible if: - You are between 30 and 70 years old - You were previously admitted to an intensive care unit (ICU) - You either had high blood sugar (hyperglycaemia) during your ICU stay without pre-existing diabetes, OR you had normal blood sugar throughout your ICU stay - Alternatively, you may qualify as a healthy volunteer matched by age, sex, and BMI You may NOT be eligible if: - You are unable to give informed consent - You are currently pregnant - You have had gestational diabetes previously - You have acute or chronic pancreatitis - You are on medications known to affect blood sugar (e.g. steroids) Talk to your doctor about whether this trial might be right for you.