RecruitingPhase 4ACTRN12618001841268

The effects of 3-months supplementation with Ubiquinol (CoQ10) on cognition and mood in healthy adults aged 60+.

The effects of 3-months supplementation with Ubiquinol (CoQ10) on cognition and mood in healthy adults aged over 60.

Sponsor

Kaneka Corporation

Enrollment

128 participants

Start Date

Mar 18, 2019

Study Type

Interventional

Conditions

Mood

Summary

We propose to study the effects of 3 month supplementation of CoQ10 on cognition versus placebo using a randomized controlled trial methodology. Our focus will be on older participants as this may be a sensitive age for cognitive improvement given that normal increasing age is associated with cognitive decline-particularly memory, the levels of CoQ10 decreases with age, there is increased deterioration in the cardiovascular system with age and finally there is increased oxidative stress with age and less anti-oxidant protection with age. All of these indicators suggest that supplementation with CoQ10 could improve cognitive function in the elderly. Apart from our sensitive cognitive battery we will also measure changes in blood levels of CoQ10 and oxidative stress (F2 Isoprostanes and glutathione peroxidase) as well as markers of cardiovascular function (Blood pressure, arterial stiffness and blood flow).

Eligibility

Sex: Both males and femalesMin Age: 60 Yearss

Plain Language Summary

Simplified for easier understanding

Coenzyme Q10 (CoQ10) is a naturally occurring substance found in every cell of the body that plays a key role in energy production and acts as an antioxidant. Levels of CoQ10 decline with age, and some research suggests this decline may contribute to cognitive changes in older adults. This study is testing whether taking a high-quality form of CoQ10 called Ubiquinol for three months improves memory, thinking speed, and mood in people aged 60 and over. Participants are randomly assigned to take either Ubiquinol or an identical-looking placebo daily for three months, with detailed cognitive testing, blood samples, and measures of cardiovascular function (blood pressure and blood flow) taken at the start and end of the study. You may be eligible if you are a non-smoking adult aged 60 or older, in generally good health, and have some subjective concerns about your memory (as measured by a questionnaire). You must have internet access for online testing. People with diabetes requiring medication, diagnosed cardiovascular disease, dementia, neurological conditions, or who are taking certain supplements or medications are not eligible.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

Ubiquinol CoQ10 Participants will be required to take one capsule orally, twice daily with food (one in the morning and one in the evening). Each capsule contains 100mg Ubiquinol, therefore partici

Ubiquinol CoQ10 Participants will be required to take one capsule orally, twice daily with food (one in the morning and one in the evening). Each capsule contains 100mg Ubiquinol, therefore participants will consume 200mg each day for 3 months. Participants will be provided with a 3-month supply of the study product at their baseline visit and will then take the capsules twice daily in their own home. Participants will be provided with a diary/log that they will be instructed to tick when they have taken their treatment each day. In addition, they will be required to return any left over treatment at their final visit so that compliance can be calculated based on capsule count.