The effects of 3-months supplementation with Ubiquinol (CoQ10) on cognition and mood in healthy adults aged 60+.

Exclusion Criteria42

• Must have normal or corrected to normal vision
• No recent history (past five years) of chronic severe illness (longer than six weeks)
• Participant is willing to maintain habitual diet (including caffeine and alcohol) and physical activity patterns throughout the study period.
• Participant is willing and able to comfortably abstain from caffeine for 10 hours prior to and throughout the test visits, (up to 3 hours).
• Participant is willing to abstain from alcohol for 24 hours and vigorous physical activity for 12 hours prior to all study visits.
• Participant is willing and able to provide 2 blood samples
• Score of 19 or above on the Memory Complaint Questionnaire (MAC-Q)
• Not currently participating in any other clinical trial
• Has access to an internet device capable of online testing
• For inclusion in the 6MWT test only – In the opinion of the Research Nurse, at low risk of an adverse event occurring during physical activity/exercise (based on responses to the Adult Pre-exercise Screening Tool).
• Participants who report any of the following will be excluded from the trial;
• Current smoker
• Psychiatric disorder requiring treatment in the previous two years. Treatment includes prescription of antidepressant, antipsychotic or other long term medication and/or referral for long term psychotherapy. It does not include brief interventions for normal life events such as exam anxiety or bereavement.
• Neurological conditions including epilepsy, Parkinson’s disease, Huntington’s Chorea and Myasthenia Gravis.
• History of dementia, stroke and other neurological conditions.
• Head trauma with loss of consciousness in the previous 6 months.
• History of Type I diabetes (insulin dependent) or Type II diabetes on treatment. (Type II diabetes and prediabetes treated with diet alone is not an exclusion).
• Cardiovascular disease
• Current endocrine, gastrointestinal or bleeding disorders.
• Uncontrolled hypertension (systolic blood pressure >160 mm Hg or diastolic blood pressure > 90 mm Hg)
• If female, pregnant or lactating.
• Alcohol or drug abuse past or present
• Other disorders affecting food metabolism, such as food allergies or intolerances
• Recent history (past 5 years) of chronic/severe illness (longer than 6 weeks)
• Taking the following (and not willing to abstain for the duration of the trial):
• i. Coenzyme Q10 , ezetimibe therapy, vitamin E, multivitamins, B vitamin complex, ginkgo biloba, fish oil, St John’s Wort, antioxidants or other cognitive enhancing dietary or herbal supplement in the 4 weeks preceding the baseline study visit
• ii. Anti-coagulant drugs (warfarin, heparin, clopidogrel, aspirin, dipyrimidole, apixiban, rivaroxiban, dabigatran, tirofiban, ticagrelor);
• iii. anti-cholinergics or acetylcholinesterase inhibitors (bethanechol (Urecholine), donepezil (Aricept), rivastigmine (Exelon), galantamine (Reminyl), edrophonium (Enoln, Reversol, Tensilon), neostigmine (Prostigmin) pyridostigmine (Mestinon)
• iv. anti-depressant medications
• v. anti-anxiety medication such as diazepam (Valium), alprazolam (Xanax) or any other antianxiety medication including benzodiazepines
• vi. Hypnotics including benzodiazepines, zolpidem and zopiclone
• vii. Illicit drugs
• viii. Antipsychotic drugs
• A score below 19 on the MAC-Q
• Vision that is not corrected to normal
• Current regular alcohol use exceeding 14 standard drinks per week for women and 28 standard drinks per week for men
• Current moderate or severe alcohol misuse disorder as defined in DSM5.
• Current substance misuse disorder as defined in DSM5 (including misuse of prescription drugs)
• Currently participating in or has participated in any other study involving an investigational product in the last 4 weeks.
• Participant under administrative or legal supervision.
• Allergy to the investigational product or formulation.
• For exclusion from the 6MWT test only – In the opinion of the Research Nurse, at high risk of an adverse event occurring during physical activity/exercise (based on responses to the Adult Pre-exercise Screening Tool).