RecruitingACTRN12619000674134

Impact of patient position and intraabdominal gas used in laparoscopic hysterectomy on optic nerve sheath diameter which reflects intracranial pressure

Impact of pneumoperitoneum and patient position on optic nerve sheath diameter in laparoscopic hysterectomies.


Sponsor

University of Health Sciences

Enrollment

50 participants

Start Date

Mar 15, 2019

Study Type

Interventional

Conditions

Summary

We hypothesized that pneumoperitoneum and Trendelenburg position applied during laparoscopic hysterectomy would impact intracranial pressure. Optic nerve sheath diameter measured with USG reflects intracranial pressure. Therefore we are enrolling patients undergoing a laparoscopic hysterectomy in our institute and measuring optic nerve sheath diameter with a linear 13-6 megahertz probe during different stages of the surgery (eg. before and after pneumoperitoneum, before and after Trendelenburg position). The primary outcome is the change in optic nerve sheath diameter with pneumoperitoneum and Trendelenburg position. The secondary outcome is postoperative nausea and vomiting and postoperative headache.


Eligibility

Sex: FemalesMin Age: 38 YearssMax Age: 78 Yearss

Plain Language Summary

Simplified for easier understanding

This study is examining how body position and the inflation of the abdomen with gas during laparoscopic (keyhole) hysterectomy affect pressure inside the skull. During this type of surgery, patients are tilted head-down (Trendelenburg position) and carbon dioxide gas is pumped into the abdomen to create space for the surgeon to work. Researchers believe this combination may increase intracranial pressure, which could potentially cause postoperative headaches or nausea. Women undergoing laparoscopic hysterectomy at the study institution will be recruited. Intracranial pressure will be estimated non-invasively by measuring the diameter of the optic nerve sheath (the tube surrounding the optic nerve) using an ultrasound probe placed on the eyelid at different points during the operation. Postoperative headache and nausea will also be tracked. You may be eligible if you are a woman aged 38–78 who is scheduled for a laparoscopic hysterectomy. People with a history of eye disease, previous eye surgery, neurological disease, or a prior transient ischaemic attack (mini-stroke) cannot participate. This observational study by the University of Health Sciences aims to improve anaesthetic management and patient safety during a very commonly performed gynaecological procedure.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

Optic nerve sheath diameter (ONSD) will be measured at six times using ultrasound : 1. Before anesthesia 2. 10 minutes after pneumoperitoneum 3. 10 minutes after Trendelenburg position 4. 60 min

Optic nerve sheath diameter (ONSD) will be measured at six times using ultrasound : 1. Before anesthesia 2. 10 minutes after pneumoperitoneum 3. 10 minutes after Trendelenburg position 4. 60 minutes after Trendelenburg position 5. 10 minutes after supine position 6.20 minutes after CO2 desufflation A laparoscopic hysterectomy will be carried out by the same surgeon who has over 10 years experience in gynecologic laparoscopy Anesthesia will be managed by the same anesthesiologists with 9 years experience ONSD measurement will be performed by a 15-year experienced radiologist.


Locations(1)

Istanbul, Turkey

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