Sevoflurane With or Without Intravenous Lidocaine Infusion Versus Propofol Anesthesia on Intracranial Pressure and Cerebral Oxygenation During Laparoscopic Hysterectomy
Effect of Sevoflurane With or Without Intravenous Lidocaine Infusion Versus Propofol Anesthesia on Intracranial Pressure and Cerebral Oxygenation During Laparoscopic Hysterectomy: A Randomized Controlled Study
Tanta University
90 participants
Feb 1, 2025
INTERVENTIONAL
Conditions
Summary
This study will be conducted to evaluate the effects of different anesthetic modalities \[sevoflurane with or without intraoperative lidocaine infusion and Propofol total intravenous anesthesia (TIVA)\] on intracranial pressure (ICP) and cerebral oxygenation assessed by non-invasive methods during laparoscopic hysterectomy (LH).
Eligibility
Inclusion Criteria4
- Age from 18 to 65 years.
- American Society of Anesthesiologists (ASA) physical status I and Ⅱ.
- Body mass index (BMI) ≤35.
- Females scheduled for laparoscopic hysterectomy.
Exclusion Criteria6
- Patients' refusal to participate in the study.
- Hypersensitivity and allergy to drugs of the study.
- Contraindication for optic nerve sheath diameter assessment. E.g., patient with pre-existing ophthalmic diseases, a history of ophthalmic surgery
- Any central nervous system or cardiovascular disease, severe hepatic or renal impairment
- Intraoperative circumstances, such as inability to perform optic nerve sheath diameter or conversion to open surgery
- If peak inspiratory pressure (PIP) exceeds 35.
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Interventions
Patients' anesthesia will be maintained by manually adjusted propofol infusion at a rate of 100-250 mic/kg/min for bispectral index (BIS) maintained between 40-60.
Sevoflurane with monitored anesthesia care (MAC) adjusted to maintain bispectral index (BIS) between 40-60 plus intravenous lidocaine infusion given as 2mg /kg IV bolus before induction then intraoperative infusion by a rate of 2 mg/kg/h until the end of surgery.
Patients will receive sevoflurane with monitored anesthesia care (MAC) adjusted to maintain bispectral index (BIS) between 40-60.
Locations(1)
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NCT07062367