Effect Of Testosterone Supplements On Anemia And Quality Of Life Amongst Patients On Regular Hemodialysis
Effect Of Testosterone Replacement On Anemia And Quality Of Life Amongst Patients On Maintenance Hemodialysis
Dr Qurat Ul Ain Azam - Pak Emirates Military Hospital
160 participants
Jan 1, 2024
Interventional
Conditions
Summary
My research focuses on relationship between testosterone replacement and its effects on anaemia and quality of life amongst patients on hemodialysis
Eligibility
Inclusion Criteria4
- Patients diagnosed with end-stage renal disease (ESRD) requiring maintenance hemodialysis.
- Patients with documented anemia, defined as haemoglobin levels < 10 g/dL
- Patients with stable medical conditions, defined as absence of acute illness or major surgical procedures within the past three months.
- Patients who have been on a stable hemodialysis regimen for at least three months prior to enrollment.
Exclusion Criteria7
- Patients with known hypersensitivity or contraindications to testosterone replacement therapy (TRT).
- Patients with active malignancy, including prostate cancer.
- Patients with uncontrolled hypertension (systolic blood pressure > 180 mmHg or diastolic blood pressure > 110 mmHg).
- Patients with severe liver disease (e.g., cirrhosis) or severe hepatic dysfunction (e.g., Child-Pugh class B or C).
- Patients with severe cardiac disease (e.g., congestive heart failure, recent myocardial infarction) or unstable cardiovascular conditions.
- Patients with a history of thromboembolic events (e.g., deep vein thrombosis, pulmonary embolism).
- Patients with significant psychiatric illness or cognitive impairment that may affect their ability to participate in the study or provide informed consent.
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Interventions
Injection testosterone enanthate 250mg subcut will be given once fortnightly for 6 months it will be administered by a dialysis nurse 30 mins after each dialysis session. Adherence would be ensured as it will be administered and documented by a dialysis nurse.
Locations(1)
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ACTRN12624001137583