Solv Multi-Pass Hemodialysis System In-Center Clinical Study

This study is testing a new type of dialysis machine called the Solv Multi-Pass Hemodialysis System, which cleans the blood of people whose kidneys no longer work. Researchers want to see if this system is safe and effective compared to standard dialysis. **You may be eligible if...** - You are 18 or older and have kidney failure (end-stage renal disease) - You are already on hemodialysis and have been stable for at least 3 months, OR you are just starting dialysis, OR you are switching from peritoneal dialysis to hemodialysis - Your blood access (dialysis port or fistula) can handle adequate blood flow - You are willing to attend all required appointments **You may NOT be eligible if...** - You weigh less than 60 kg (132 lbs) or more than 110 kg (242 lbs) - You have a history of skipping scheduled dialysis sessions - You are scheduled for a kidney transplant or switching to peritoneal dialysis within 2 months - You have had a major surgery or heart event in the last 3 months - You have active infection, HIV, Hepatitis B or C, or a serious blood clotting disorder - You are pregnant or breastfeeding - You have had unstable blood pressure during dialysis recently Talk to your doctor to see if this trial is right for you.