Use of CA125 and Complementary Biomarkers for the Early Detection of Ovarian Cancer in Low Risk Women

This study is testing a blood test (CA-125) combined with ultrasound to see if it can detect ovarian cancer earlier in postmenopausal women who are at average risk. You may be eligible if: - You are a woman between 50 and 74 years old - You have gone through menopause (no periods for at least 12 months) - You have at least one ovary - You are currently cancer-free and have not had chemotherapy or radiation in the past 12 months - You are willing to have annual blood tests and ultrasounds if needed - You have a gynecologist or qualified doctor for follow-up care You may NOT be eligible if: - You are younger than 50 or older than 75 - You have both ovaries removed - You currently have an active non-ovarian cancer - You are at high genetic risk for ovarian cancer (e.g., known BRCA1 or BRCA2 gene change, strong family history of ovarian or early-onset breast cancer, Ashkenazi Jewish heritage with close relatives with these cancers, or Lynch Syndrome/HNPCC) - You have had a non-ovarian cancer and finished treatment less than 12 months ago (except basal cell skin cancer) - You have a mental health condition that prevents you from giving fully informed consent Talk to your doctor to see if this trial is right for you.