Multimodal Imaging Assessment of the Inflammatory Atheromatous Plaque
Multimodal Assessment of the Inflammatory Atheromatous Plaque : Comparison Between 68Ga-NODAGA-RGD PET/CT, 18F-FDG PET/CT, MRI AND US
University of Lausanne Hospitals
20 participants
Apr 1, 2012
INTERVENTIONAL
Conditions
Summary
The present study aims at assessing the ability of 68Ga-NODAGA-RGD PET/CT for the detection of inflammatory atheromatous plaques in the carotid arteries, compared to 18F-FDG PET/CT, MRI and US and to determine the contribution of each imaging technique. Current gold standard for inflammation is histopathology. Hypothesis : 68Ga-NODAGA-RGD might give a better initial evaluation of patients with atheromatous plaques in the carotid artery eligible for endarterectomy.
Eligibility
Inclusion Criteria4
- age \<= 85 years
- Karnofsky \>= 80%
- patient with indication ofr carotid endarterectomy
- signed consent form
Exclusion Criteria6
- indication for surgery other than endarterectomy \<14 days
- contraindication to surgery
- contraindication to MRI
- contraindication to gadolinium injection (stage 4/5 kidney insufficiency, GFR\<30ml/min/1.73m2)
- pregnancy, breastfeeding
- lack of discernment
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Interventions
200 MBq 68 Ga-NODAGA-RGD will be administered i.v. and images centred on the carotid area acquired
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT01608516