RecruitingNot ApplicableNCT02016430

Gut Flora Metabolite Reduction After Dietary Intervention (GRADY)

Sponsor

The Cleveland Clinic

Enrollment

170 participants

Start Date

Apr 4, 2014

Study Type

INTERVENTIONAL

Conditions

Cardiovascular Risk Factor Dietary Modification

Summary

Our group has recently identified the association between gut-flora-mediated carnitine and phosphatidylcholine metabolism, specifically trimethylamine-N-oxide (TMAO), and cardiovascular risk. This study investigates the ability for dietary intervention to modulate TMAO levels.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a behavioral approach called MeLT Dietary intervention, a behavioral approach called MeLT dietary intervention with TMAO, and others for people with cardiovascular risk factor and dietary modification. The study is currently recruiting participants at 1 location. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALMeLT Dietary intervention

Mediterranean diet containing food with low TMAO content.

BEHAVIORALTLC Dietary intervention

Standard American Heart Association (AHA) recommendations for dietary counseling.

BEHAVIORALMeLT dietary intervention with TMAO

Mediterranean diet containing food with low TMAO content with TMAO levels provided to the subject for guidance.

Locations(1)

Cleveland Clinic

Cleveland, Ohio, United States

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NCT02016430

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