Expanded Access Protocol Using CD3+/CD19+ Depleted PBSC

This trial is offering stem cell transplants using donor cells that have been specially filtered to remove certain immune cells (CD3+ and CD19+ cells), for patients who need a transplant but are not eligible for other available studies. **You may be eligible if...** - You do not have a fully matched sibling donor - You need a donor stem cell transplant but do not qualify for other current clinical studies using the same technique - You have one of these conditions: a metabolic storage disease, bone marrow failure syndrome, immune deficiency, hemoglobin disorder (like sickle cell), or blood cancer such as leukemia or lymphoma **You may NOT be eligible if...** - A fully matched sibling donor is available to you - You are eligible for another open institutional study using the same transplant approach - Your general health is too poor to undergo transplant Talk to your doctor to see if this trial is right for you.