RecruitingNCT02391519

Effects of High Altitude on AMPK Activation

Effects of High Altitude on 5' Adenosine Monophosphate-activated Protein Kinase (AMPK) Activation and Peroxisome Proliferator-activated Receptor Gamma (PPARγ) Regulation

Sponsor

University of Colorado, Denver

Enrollment

84 participants

Start Date

Jan 1, 2016

Study Type

OBSERVATIONAL

Conditions

Pregnancy Preeclampsia IUGR

Summary

Pregnancy elicits adaptive changes in uteroplacental blood flow, which are altered at high altitude and may contribute to the observed 3-fold increase in intrauterine growth restriction (IUGR) and preeclampsia (PreE). The investigators propose to collect myometrial, cord blood, and placental tissue samples from women at high altitude (Summit County) and low altitude (Denver) in Colorado in order to determine if residence at altitude during pregnancy changes the vasoreactivity of myometrial arteries (MA). If altered MA vasoreactivity is found, further studies may be able to link these changes to the increased rates of PreE and IUGR at altitude and contribute to the understanding of these two disorders.

Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 45 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at how altitude affects a natural cellular energy system (called AMPK) in pregnant women who are scheduled for planned cesarean deliveries, comparing women giving birth at a low-altitude hospital (Denver) to those at a high-altitude hospital (Summit County, Colorado). **You may be eligible if...** - You are a woman scheduled for a planned (non-emergency) cesarean delivery at approximately 39 weeks of pregnancy - Your delivery is at the University of Colorado Hospital or St. Anthony's Summit Medical Center **You may NOT be eligible if...** - You have diabetes or gestational diabetes - You have any blood pressure condition during pregnancy (such as preeclampsia) - You are a current smoker - You are carrying more than one baby (twins, triplets, etc.) - You are having a preterm delivery Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDURECollection of myometrial, cord blood, and placental tissue samples

We propose to collect myometrial, cord blood, and placental tissue samples from women at high altitude (Summit County) and low altitude (Denver) in Colorado in order to determine if residence at altitude during pregnancy changes the vasoreactivity of myometrial arteries (MA).