The Neurobiology of Two Distinct Types of Progressive Apraxia of Speech

This study investigates two distinct types of progressive apraxia of speech (PAOS) — a neurological condition where the brain loses its ability to coordinate the mouth movements needed for speech. Researchers use brain scans and speech tests to understand the underlying brain changes that cause this condition. You may be eligible if: - You are 18 years or older and speak English as your primary language - You have a progressive worsening of speech ability (not due to a stroke or injury) - You have been diagnosed with apraxia of speech by a speech-language pathologist - Your speech is still understandable enough for evaluation - You have a family member or caregiver who can provide an independent account of your functioning You may NOT be eligible if: - Your speech is too impaired for diagnosis - Your speech problems are caused by a stroke, brain injury, or another neurological disease - You have aphasia or dysarthria more severe than your apraxia of speech - You are pregnant or breastfeeding - You cannot have MRI scans (e.g., metal implants, severe claustrophobia) Talk to your doctor to see if this trial is right for you.