Primary Progressive Aphasia Clinical Trials

14 recruiting

Primary Progressive Aphasia Trials at a Glance

21 actively recruiting trials for primary progressive aphasia are listed on ClinicalTrialsFinder across 6 cities in 6 countries. The largest study group is Not Applicable with 9 trials, with the heaviest enrollment activity in Toronto, Philadelphia, and Rochester. Lead sponsors running primary progressive aphasia studies include Mayo Clinic, Maya Henry, and Johns Hopkins University.

Browse primary progressive aphasia trials by phase

Treatments under study

About Primary Progressive Aphasia Clinical Trials

Looking for clinical trials for Primary Progressive Aphasia? There are currently 14 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Primary Progressive Aphasia trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Primary Progressive Aphasia clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 21 trials

Recruiting

The Neurobiology of Two Distinct Types of Progressive Apraxia of Speech

Apraxia of SpeechPrimary Progressive AphasiaNon-fluent Aphasia+1 more
Mayo Clinic47 enrolled1 locationNCT03313011
Recruiting
Phase 2

Clinical Study of Neflamapimod in Patients With Primary Progressive Aphasia

Nonfluent Variant Primary Progressive Aphasia (nfvPPA)
EIP Pharma Inc20 enrolled7 locationsNCT07033481
Recruiting
Not Applicable

Long Term Effect of Brain Stimulation in PPA

Primary Progressive Aphasia(PPA)
Hospital San Carlos, Madrid80 enrolled1 locationNCT07158216
Recruiting
Not Applicable

Remotely-supervised Neuromodulation in PPA

Primary Progressive Aphasia(PPA)Progressive AphasiaProgressive Aphasia in Alzheimer's Disease+3 more
Maya Henry80 enrolled2 locationsNCT07260253
Recruiting
Not Applicable

Intervention for Communication Quality of Life in Primary Progressive Aphasia

Primary Progressive Aphasia(PPA)Progressive AphasiaLogopenic Progressive Aphasia (LPA)+9 more
Maya Henry30 enrolled1 locationNCT07219680
Recruiting

Language in Primary Progressive Aphasia

Primary Progressive Aphasia
Northwestern University500 enrolled1 locationNCT00537004
Recruiting

Speech and Language Interventions for Italian People With PPA

Primary Progressive Aphasia(PPA)
Istituti Clinici Scientifici Maugeri SpA30 enrolled2 locationsNCT06739967
Recruiting

UPenn Observational Research Repository on Neurodegenerative Disease

Primary Progressive Aphasia(PPA)Frontotemporal Degeneration(FTD)Familial Frontotemporal Lobar Degeneration (fFTLD)+2 more
University of Pennsylvania1,000 enrolled1 locationNCT04715399
Recruiting

Improving Prognostic Confidence in Neurodegenerative Diseases Causing Dementia Using Peripheral Biomarkers and Integrative Modeling

DementiaAlzheimer DiseaseParkinson Disease+7 more
University Health Network, Toronto500 enrolled4 locationsNCT06529744
Recruiting
Not Applicable

Cognitive Reserve and Response to Speech-Language Intervention in Bilingual Speakers With Primary Progressive Aphasia

DementiaAlzheimer DiseaseCommunication Disorders+11 more
University of Texas at Austin60 enrolled3 locationsNCT05741853
Recruiting
Phase 4

Longitudinal Multi-Modality Imaging in Progressive Apraxia of Speech

Apraxia of SpeechPrimary Progressive AphasiaPPA+2 more
Mayo Clinic50 enrolled1 locationNCT01818661
Recruiting
Phase 2

Transcranial Direct Current Stimulation in the Treatment of Primary Progressive Aphasia

Primary Progressive AphasiaLogopenic Progressive AphasiaNon-Fluent Primary Progressive Aphasia
Johns Hopkins University180 enrolled3 locationsNCT05386394
Recruiting
Not Applicable

Targeting Language-specific and Executive-control Networks With Transcranial Direct Current Stimulation in Logopenic Variant PPA

Primary Progressive AphasiaLogopenic Progressive Aphasia
Johns Hopkins University60 enrolled1 locationNCT03887481
Recruiting

ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

Amyotrophic Lateral SclerosisCorticobasal Degeneration (CBD)Progressive Supranuclear Palsy (PSP)+11 more
Mayo Clinic2,100 enrolled27 locationsNCT04363684
Recruiting
Phase 2

Communication Bridge 3 Study

Primary Progressive Aphasia
University of Chicago200 enrolled1 locationNCT06191198
Recruiting
Phase 2

Nabilone for Agitation in Frontotemporal Dementia

Frontotemporal DementiaPrimary Progressive AphasiaFTD+3 more
Simon Ducharme, MD45 enrolled7 locationsNCT05742698
Recruiting
Early Phase 1

Educational Support Group Program for Bilingual and Spanish-speaking Carepartners and People With Progressive Aphasia

DementiaAlzheimer DiseaseProgressive Aphasia+3 more
University of Texas at Austin120 enrolled1 locationNCT06511752
Recruiting
Not Applicable

Enhancing Language Function in Aphasia

Primary Progressive AphasiaLanguage DisordersAphasia, Acquired+1 more
University of Arizona30 enrolled1 locationNCT05443633
Recruiting
Not Applicable

Enhancing Language Function in Primary Progressive Aphasia

Primary Progressive Aphasia
University of Arizona20 enrolled1 locationNCT04920318
Recruiting
Not Applicable

A Multimodal Approach for Clinical Diagnosis and Treatment of Primary Progressive Aphasia, MAINSTREAM ID:3430931

Primary Progressive Aphasia
IRCCS Centro San Giovanni di Dio Fatebenefratelli60 enrolled4 locationsNCT05730023