Longitudinal Multi-Modality Imaging in Progressive Apraxia of Speech

This Mayo Clinic study uses multi-modality brain imaging (MRI and PET scans) to track brain changes over time in people with progressive apraxia of speech (AOS) — a neurological condition affecting the ability to plan and sequence movements needed for speaking, distinct from aphasia or dysarthria. The goal is to better understand how the condition progresses. You may be eligible if: - You are 18 years or older - You have been diagnosed with neurodegenerative apraxia of speech at Mayo Clinic - You have an available informant (someone who knows you well) You may NOT be eligible if: - Your speech/language problems are caused by another condition (stroke, brain injury, developmental syndrome) - You are pregnant, postpartum, or breastfeeding - You have contraindications to MRI (e.g., pacemaker, metal in the head, severe claustrophobia) - You take medications that might affect brain structure or metabolism (e.g., chemotherapy) Talk to your doctor to see if this trial is right for you.