RecruitingPhase 4NCT01818661

Longitudinal Multi-Modality Imaging in Progressive Apraxia of Speech

Sponsor

Mayo Clinic

Enrollment

50 participants

Start Date

Jul 1, 2018

Study Type

INTERVENTIONAL

Conditions

Apraxia of Speech Primary Progressive Aphasia PPA Non-fluent Aphasia Primary Progressive Non-fluent Aphasia

Summary

The study is designed to determine the relationship between structural and functional changes in the brain on imaging and progression of speech and language, neurological and neuropsychological features in patients with neurodegenerative apraxia of speech (AOS).

Eligibility

Min Age: 18 Years

Exclusion Criteria4

Subjects with concurrent illnesses that could account for speech and language deficits, such as traumatic brain injury, strokes or developmental syndromes will be excluded.
Women that are pregnant or post-partum and breast-feeding will be excluded. All women who can become pregnant must have a pregnancy test no more than 48 hours before the PET scan.
Subjects will also be excluded if MRI is contraindicated (metal in head, cardiac pace maker, e.t.c.), if there is severe claustrophobia, if there are conditions that may confound brain imaging studies (e.g. structural abnormalities, including subdural hematoma or intracranial neoplasm), or if they are medically unstable or are on medications that might affect brain structure or metabolism,(e.g. chemotherapy).
Subjects will also be excluded if they do not have an informant, or do not consent to research.

Print for Your Doctor

Interested in this trial?

Get notified about updates and connect with the research team.