RecruitingNCT06529744

Improving Prognostic Confidence in Neurodegenerative Diseases Causing Dementia Using Peripheral Biomarkers and Integrative Modeling

Sponsor

University Health Network, Toronto

Enrollment

500 participants

Start Date

Nov 11, 2023

Study Type

OBSERVATIONAL

Conditions

Dementia Alzheimer Disease Parkinson Disease Corticobasal Syndrome Dementia With Lewy Bodies Mild Cognitive Impairment Frontotemporal Dementia Progressive Supranuclear Palsy Primary Progressive Aphasia Vascular Dementia

Summary

To develop a model to predict disease progression in a large cohort of patients across a variety of neurodegenerative diseases, including Mild Cognitive Impairment (MCI) and dementia due to any neurodegenerative disease, including Alzheimer's Disease (AD), Lewy Body Disease (LBD), Vascular Disease (VaD) and Frontotemporal lobar degeneration (FTLD).

Eligibility

Min Age: 30 YearsMax Age: 95 Years

Inclusion Criteria4

Possible or probable diagnosis of MCI or early dementia
Age 30-95
Study partner who has some weekly contact with patient. Some of the neuropsychological assessment require collateral from close contacts to assess cognition and functioning. Since neurodegenerative diseases can be associated with reduced cognition, including reduced awareness of one's own impairments, participants will be assessed for their capacity to consent at all study visits.
Must, in the opinion of the site investigator, be able to complete most study procedures.