RecruitingNCT06529744

Improving Prognostic Confidence in Neurodegenerative Diseases Causing Dementia Using Peripheral Biomarkers and Integrative Modeling

Sponsor

University Health Network, Toronto

Enrollment

500 participants

Start Date

Nov 11, 2023

Study Type

OBSERVATIONAL

Conditions

Dementia Alzheimer Disease Parkinson Disease Corticobasal Syndrome Dementia With Lewy Bodies Mild Cognitive Impairment Frontotemporal Dementia Progressive Supranuclear Palsy Primary Progressive Aphasia Vascular Dementia

Summary

To develop a model to predict disease progression in a large cohort of patients across a variety of neurodegenerative diseases, including Mild Cognitive Impairment (MCI) and dementia due to any neurodegenerative disease, including Alzheimer's Disease (AD), Lewy Body Disease (LBD), Vascular Disease (VaD) and Frontotemporal lobar degeneration (FTLD).

Eligibility

Min Age: 30 YearsMax Age: 95 Years

Plain Language Summary

Simplified for easier understanding

This study is using blood-based biomarkers (measurable biological signals) combined with brain imaging and cognitive testing to better predict the progression of neurodegenerative diseases (conditions that cause brain cells to die over time, like Alzheimer's). The goal is to give patients and doctors more confidence about what to expect. **You may be eligible if...** - You are between 30 and 95 years old - You have a possible or probable diagnosis of mild cognitive impairment (early memory problems) or early dementia - You have a study partner (family member or friend) who has regular contact with you **You may NOT be eligible if...** - You do not have a diagnosis of MCI or early dementia - You do not have a study partner available - You are outside the age range - You have a different cause of cognitive decline (such as a medication side effect) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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