RecruitingNot ApplicableNCT03343873

The Effects of Different Anesthetics on Functional Connectivity

The Effects of Different Anesthetics on Functional Connectivity in Volunteers and Patients With Brain Tumor (ACTION)

Sponsor

Beijing Tiantan Hospital

Enrollment

240 participants

Start Date

Apr 1, 2017

Study Type

INTERVENTIONAL

Conditions

Sedation

Summary

This research is a prospective cohort study. The aim of the study is to determine different levels of sedative mechanism and the effect on brain functional connectivity of midazolam, dexmedetomidine and propofol.

Eligibility

Sex: MALEMin Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study is using brain MRI to examine how different types of anaesthesia affect the way different brain regions communicate with each other (called functional connectivity), helping doctors better understand and improve the safety of anaesthesia. **You may be eligible if...** - You are a male between 18 and 65 years old - You are either a healthy volunteer OR a brain tumour patient - You have completed at least senior high school education - You are willing to sign informed consent **You may NOT be eligible if...** - You have a metal implant or other reason you cannot have an MRI - You have heart, lung, liver, kidney, or other serious health problems - You have had major surgery or anaesthesia before - You have a history of drug abuse or alcoholism - You have known allergy to the study anaesthetic drugs Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGMidazolam

Midazolam was administered intravenously at a dose of 0.1 mg / kg followed by continuous intravenous injection at 0.03 mg / kg / h and maintained until the course of the scan.

DRUGPropofol

Propofol group 1mg / kg intravenous injection, followed by 2mg / kg / h continuous intravenous injection, and maintained to the scanning process;

DRUGDexmedetomidine

Dexmedetomidine group with total amount of 1μg / kg, infusion time 15min, followed by 0.6μg / kg / h, and maintained to the scanning process;