The Effects of Different Anesthetics on Functional Connectivity
The Effects of Different Anesthetics on Functional Connectivity in Volunteers and Patients With Brain Tumor (ACTION)
Beijing Tiantan Hospital
240 participants
Apr 1, 2017
INTERVENTIONAL
Conditions
Summary
This research is a prospective cohort study. The aim of the study is to determine different levels of sedative mechanism and the effect on brain functional connectivity of midazolam, dexmedetomidine and propofol.
Eligibility
Inclusion Criteria4
- \. Male, 18 \~ 65 years old
- \. Healthy Volunteer / Brain Tumor Patients
- \. Senior high school and above
- \. Sign informed consent
Exclusion Criteria7
- \. In vivo implant MRI check taboo
- \. Cardiopulmonary liver and kidney and other systemic complications
- \. History of major surgical anesthesia
- \. Abuse of drugs, alcoholism history
- \. Test drug allergy history
- \. Claustrophobia
- \. Left hand
Interventions
Midazolam was administered intravenously at a dose of 0.1 mg / kg followed by continuous intravenous injection at 0.03 mg / kg / h and maintained until the course of the scan.
Propofol group 1mg / kg intravenous injection, followed by 2mg / kg / h continuous intravenous injection, and maintained to the scanning process;
Dexmedetomidine group with total amount of 1μg / kg, infusion time 15min, followed by 0.6μg / kg / h, and maintained to the scanning process;
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT03343873