RecruitingNCT03451383

Older Breast Cancer Patients: Risk for Cognitive Decline

Older Breast Cancer Patients: Risk for Cognitive Decline. The Thinking and Living With Cancer (TLC) Study


Sponsor

Georgetown University

Enrollment

1,700 participants

Start Date

Aug 1, 2010

Study Type

OBSERVATIONAL

Conditions

Summary

The goal of this study is to evaluate the impact of systemic therapy on cognition in older breast cancer patients, explore change in APE, LM and Cognition domains, measure associations between cognitive decline and QOL, and describe how genetic polymorphisms, inflammatory biomarkers, sleep and physical measures moderate cognitive outcomes. This study is being done nationally, with recruiting sites at Georgetown University, Montgomery General Hospital, Virginia Cancer Specialists, Washington Hospital Center, Reston Breast Care Specialists, Memorial Sloan-Kettering, Moffitt Cancer Center, City of Hope National Medical Center, Hackensack University Medical Center, Indiana University and University of California, Los Angeles.


Eligibility

Sex: FEMALEMin Age: 60 YearsMax Age: 105 Years

Plain Language Summary

Simplified for easier understanding

This study is examining whether older women being treated for breast cancer are at greater risk of memory and thinking problems (cognitive decline) during and after treatment, and what factors might predict who is most at risk. **You may be eligible if...** - You are a woman aged 60 or older - You have been newly diagnosed with breast cancer (stages 0–3) confirmed by tissue testing, or are planning to receive treatment before surgery - You are able to communicate in English well enough to complete the study assessments - If taking psychiatric medications (such as antidepressants or anti-anxiety medications), your dose has been stable for at least 2 months **You may NOT be eligible if...** - You have a previous diagnosis of dementia, Alzheimer's disease, or another condition known to cause cognitive problems - You cannot communicate in English sufficiently - You are younger than 60 - You have stage 4 (metastatic) breast cancer Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(1)

Georgetown University

Washington D.C., District of Columbia, United States

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NCT03451383


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