Exploring the Utility of Hyperpolarized 129Xe MRI in Healthy Volunteers and Patients With Lung Disease

This study is testing a new type of MRI that uses a special inhaled gas (hyperpolarized xenon-129) to get clearer pictures of how air moves through the lungs, comparing results in people with lung disease versus healthy volunteers. **You may be eligible if...** - You are between 18 and 85 years old - You have a diagnosed lung condition such as asthma, COPD, emphysema, bronchiectasis, pulmonary fibrosis, or sarcoidosis (for the lung disease group) - You are a healthy volunteer with no history of lung or respiratory problems (for the healthy group) - You can read and understand English - You are able to cooperate with breathing instructions during the MRI scan **You may NOT be eligible if...** - You are pregnant - You have a pacemaker, metal implants, or other devices in your body that are not safe for MRI - You are unable to perform breathing tests (spirometry) - You have a condition that would make MRI scanning unsafe - You have any serious mental or physical condition that would prevent you from safely completing the tests Talk to your doctor to see if this trial is right for you.