RecruitingPhase 4NCT03471117

Pioglitazone to Reduce Sympathetic Overactivity in CKD Patients

Targeting ADMA With Pioglitazone to Reduce Sympathetic Overactivity in CKD Patients

Sponsor

The University of Texas at Arlington

Enrollment

28 participants

Start Date

Apr 1, 2018

Study Type

INTERVENTIONAL

Conditions

Chronic Kidney Diseases

Summary

Chronic kidney disease (CKD) is associated with a higher risk of cardiovascular disease and death. An overactive sympathetic nervous system in CKD patients is one of the major mechanisms increasing the cardiovascular risks in this patient population. Recently, some studies have shown that a drug typically used to improve glucose control (pioglitazone) may also reduce sympathetic nerve activity and improve blood vessel function. The goal of this study is to determine whether a short-term treatment with pioglitazone can reduce sympathetic nerve impulses throughout the body in CKD patients.

Eligibility

Min Age: 35 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether pioglitazone — a medication normally used for type 2 diabetes — can reduce overactivity of the nervous system (specifically, the sympathetic nervous system, which controls things like heart rate and blood pressure) in patients with moderate-to-severe chronic kidney disease. **You may be eligible if...** - You are between 35 and 70 years old - You have Stage 3 or 4 chronic kidney disease (moderate to severe reduction in kidney function, with a filtration rate between 15 and 59) **You may NOT be eligible if...** - You are allergic to glitazone-type medications - You have had a heart attack, heart failure, or angina (chest pain) - You have a history of kidney stones - You have liver disease or abnormal liver blood tests - You are anemic (low hemoglobin below 8 g/dL) - You are currently being treated for cancer - You have had an organ transplant or are on immunosuppressant drugs - You are HIV positive - You are pregnant or breastfeeding - You currently smoke - You take Dilantin (phenytoin) or oral contraceptives - You have a history of low blood sugar episodes Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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