RecruitingEarly Phase 1NCT03561376

Zinc Oxide Versus Petrolatum Following Skin Surgery

Zinc Oxide Versus Petrolatum Following Skin Surgery: A Head-to-head, Prospective, Split-scar Study


Sponsor

Melissa Pugliano-Mauro

Enrollment

30 participants

Start Date

Sep 1, 2021

Study Type

INTERVENTIONAL

Conditions

Summary

Patients undergoing routine surgery in the Department of Dermatology for any indication on non-scalp skin and closed in linear fashion with scar greater than or equal to 4.5cm in length will be invited to participate in this split scar, head to head study comparing zinc oxide and petrolatum. Patients will apply respective ointments to each half of scar daily for one month and maintain a log of these activities. They will be seen at 1 week, 4 weeks, 8 weeks, and 6 months post-operatively for photographic scar assessment and to complete the patient portion of the Patient and Observer Scar Assessment Scale (POSAS), a quantitative objective assessment of scar appearance. Trained observers (board-certified dermatologists) will score the observer portion of the scale. POSAS outcomes, post-operative infections, linear density of epidermal seal will be assessed at the 1 week, 4 weeks, 8 weeks, and 6 months post-operative periods and compared between the two groups. Participants will have parking validated for all visits and upon completion of all portions of the study will receive a standardized skin care gift bag containing samples for hypoallergenic skin care products (washes, moisturizers, etc.).


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

After skin surgery — such as removal of a mole, skin cancer, or cyst — the wound is typically covered with a topical ointment to keep it moist and promote healing. Petrolatum (plain petroleum jelly) is the current standard, but zinc oxide ointment is sometimes used as an alternative. This trial compares how well wounds heal under zinc oxide versus petrolatum applied to linear surgical closures on the body (excluding the scalp) after skin procedures. Scar quality, wound healing speed, and infection rates are compared between the two products. If zinc oxide proves equivalent or superior, it could become a practical, affordable alternative in wound care. You may be eligible if: - You are 18 years old or older - You have had a linear skin surgery closure at a non-scalp site - Your incision is at least 4.5 cm long - Your wound is not infected You may NOT be eligible if: - You are under 18 years old - Your surgical scar is visibly asymmetric - You have a known allergy to topical zinc oxide - Your surgical site appears grossly infected Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DRUGTopical zinc oxide vs. petrolatum post-surgical scars

Following linear closure on non-scalp skin with scar length \> 4.5 cm, incision site will be "split" and petrolatum applied to one half and zinc oxide ointment to the other half daily for one month following surgery.


Locations(1)

UPMC Dermatology St. Margaret

Pittsburgh, PA, Pennsylvania, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT03561376


Related Trials