Degenerative disease Clinical Trials

72 recruitingLast updated: May 21, 2026

There are 72 actively recruiting degenerative disease clinical trials across 31 countries. Studies span Not Applicable, Phase 2, Phase 3, Phase 4, Early Phase 1, Phase 1. Top locations include Hefei, Anhui, China, Tianjin, Tianjin Municipality, China, Beijing, China. Updated daily from ClinicalTrials.gov.


Degenerative disease Trials at a Glance

72 actively recruiting trials for degenerative disease are listed on ClinicalTrialsFinder across 6 cities in 31 countries. The largest study group is Not Applicable with 25 trials, with the heaviest enrollment activity in Hefei, Tianjin, and Beijing. Lead sponsors running degenerative disease studies include University of Exeter, Tianjin Medical University, and Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta.

Browse degenerative disease trials by phase

About Degenerative disease Clinical Trials

Looking for clinical trials for Degenerative disease? There are currently 4 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Degenerative disease trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Degenerative disease clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 72 trials

Recruiting

The Neurodevelopmental and Behavioral Phenotyping Screening Protocol

AutismNeurologic DisordersNeurodegenerative Disease+1 more
National Institute of Mental Health (NIMH)5,000 enrolled1 locationNCT00271622
Recruiting

Clinical Performance and Safety of the Unicompartmental Univation® XF Pro Implant

GonarthritisDegenerative disease
Aesculap AG150 enrolled4 locationsNCT06657248
Recruiting

100-Year Human Aging Study

Disability PhysicalNeoplasmsCardiovascular Diseases+12 more
Longevity Metrics, Inc.10,000 enrolled1 locationNCT07563777
Recruiting
Not Applicable

Pre-operative Risk Assessment Combined With Targeted Intervention in the Chinese Elderly With Spine Surgery II

PrehabilitationFrail ElderlyLumbar Degenerative Disease+2 more
Xuanwu Hospital, Beijing248 enrolled4 locationsNCT07396077
Recruiting
Not Applicable

Retinal Hyperspectral Imaging in Neurodegenerative Diseases

DementiaAlzheimer DiseaseParkinson Disease+5 more
Center for Eye Research Australia930 enrolled1 locationNCT07545473
Recruiting
Not Applicable

Study to Evaluate the Efficacy and Safety of ATNC-MDD V1(TMS With Cognitive Training) in Mild Alzheimer's Dementia

DementiaBrain DiseasesCentral Nervous System Diseases+5 more
Advanced Technology & Communications180 enrolled11 locationsNCT06088121
Recruiting

Patient Reported Outcome Measurements Registration in Spinal Pathologies and Neuromodulation

PainCervical PainLumbar Pain Syndrome+3 more
Jessa Hospital5,000 enrolled1 locationNCT07552519
Recruiting
Not Applicable

Comparison of Clinical Outcomes, Complications Rate and Treatment Costs of Mini-TLIF and MIDLIF in the Treatment of Discogenic Low Back Pain

Lumbar Disc DegenerationDegenerative Disc Disease (DDD)Lumbar Degenerative Disease+1 more
Copernicus Memorial Hospital100 enrolled1 locationNCT07127380
Recruiting
Phase 3

A Phase 3 Study of NTLA-2001 in ATTRv-PN

Nervous system diseasePeripheral nervous system diseaseAmyloidosis+17 more
Intellia Therapeutics60 enrolled14 locationsNCT06672237
Recruiting
Not Applicable

3D Printers for Autonomy in the Care of Inpatients in Continuing and Rehabilitation Care

Neuro-Degenerative Disease
Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer75 enrolled2 locationsNCT07087574
Recruiting
Not Applicable

Neuropsychological and Brain Medical Imaging Study in Patients With Brain Damage 2

Cerebrovascular DisordersDevelopmental DisabilityBrain Lesion+1 more
University Hospital, Caen400 enrolled1 locationNCT03586258
Recruiting
Phase 3

A Study of Donanemab (LY3002813) in Participants With Early Symptomatic Alzheimer's Disease (TRAILBLAZER-ALZ 5)

DementiaBrain DiseasesCentral Nervous System Diseases+6 more
Eli Lilly and Company1,500 enrolled141 locationsNCT05508789
Recruiting

Exploring the Olfactory Mucosa, Blood and Urine for the Identification of Early Biomarkers of Parkinson's Disease, Atypical Parkinsonisms and Neurocognitive Disorders Due to Lewy Body Disease

Parkinson DiseaseMSA - Multiple System AtrophyLewy Body Dementia (LBD)+2 more
Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta180 enrolled3 locationsNCT06846658
Recruiting
Not Applicable

Dyadic Mindfulness for People With Parkinson's Disease and Their Caregivers

MindfulnessMovement DisordersCaregivers+4 more
The University of Hong Kong200 enrolled1 locationNCT06821230
Recruiting

Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq)

Movement DisordersMotor Neuron DiseaseHereditary Spastic Paraplegia+3 more
Boston Children's Hospital200 enrolled1 locationNCT05354622
Recruiting
Phase 2

Allopregnanolone Regenerative Therapeutic for Mild Alzheimer's Disease

Alzheimer DementiaLate Onset Alzheimer DiseaseNeurodegenerative Diseases
University of Arizona100 enrolled10 locationsNCT04838301
Recruiting
Not Applicable

Feasibility of Wearables in Dementia Care in Rural Taiwan

Circadian RhythmAlzheimer's DementiaNeuropsychiatric Symptoms Related to Neurodegenerative Disease+2 more
China Medical University Hospital20 enrolled1 locationNCT07249918
Recruiting

Retinal Imaging in Neurodegenerative Disease

Traumatic Brain InjuryHuntington DiseaseNeuro-Degenerative Disease+12 more
Duke University2,000 enrolled1 locationNCT03233646
Recruiting

A Prospective Natural History and Outcome Measure Discovery Study of Charcot-Marie-Tooth Disease, Type 4J

Peripheral NeuropathyNeuro-Degenerative DiseaseNeuromuscular Diseases
Elpida Therapeutics SPC20 enrolled3 locationsNCT06151600
Recruiting
Not Applicable

Slowing Cognitive Decline in Alpha-synucleinopathies by Enhancing Physical Activity

Brain DiseasesCentral Nervous System DiseasesParkinson Disease+7 more
University Hospital, Bonn130 enrolled1 locationNCT07324330