Additional Hyperbaric Oxygen After Lower Extremity Amputation

This study investigates whether adding hyperbaric oxygen therapy (HBOT) after lower limb amputation helps patients heal better and reduces wound complications. HBOT involves breathing pure oxygen inside a pressurized chamber, which dramatically increases oxygen delivery to tissues and may promote wound healing. Lower extremity amputations — often due to diabetes, infection, poor blood circulation, or tissue death — carry significant risks of wound complications and rehospitalization. HBOT is already used in some wound care settings, and this trial specifically tests its benefit after amputation surgery. Adults aged 18–90 who have undergone a lower limb amputation for qualifying reasons and who are enrolled within 7 days of their final surgery are eligible. You may be eligible if you: - Are between 18 and 90 years of age - Have had a lower extremity amputation due to chronic wound, osteomyelitis (bone infection), ischemia (poor blood flow), or necrosis (tissue death) - Have been cleared for hyperbaric oxygen therapy by an anesthesiologist or Hyperbaric Medicine Physician - Can attend follow-up appointments - Are enrolled within 7 days of your final surgery You may NOT be eligible if you: - Are currently pregnant - Have dementia Talk to your doctor to see if this trial is right for you.