Radiotracer-Based Perfusion Imaging of Patients With Peripheral Arterial Disease
Radiotracer Imaging of Skeletal Muscle Perfusion in Patients With Peripheral Artery Disease
Nationwide Children's Hospital
192 participants
Feb 17, 2017
INTERVENTIONAL
Conditions
Summary
The aim of this clinical study is to 1) establish a healthy database for nuclear perfusion imaging of the lower extremities and 2) assess the prognostic value of radiotracer-based perfusion imaging for predicting clinical outcomes in patients with peripheral artery disease (PAD) who are undergoing lower extremity revascularization procedures. We hypothesize that radiotracer imaging of the lower extremities will provide a sensitive non-invasive imaging tool for quantifying regional abnormalities in skeletal muscle perfusion and evaluating responses to medical treatment.
Eligibility
Inclusion Criteria4
- At least 18 years of age
- Evidence of significant obstructive disease for one or multiple lower extremity arteries, as identified by prior ABI, TBI, CT angiography, ultrasound, or MR imaging.
- At least 18 years of age
- No evidence or prior diagnosis of peripheral artery disease based on chart review and standard vascular screening.
Exclusion Criteria8
- Unable to give informed consent or follow-up
- Pregnant or nursing
- Under the age of 18
- No history of peripheral artery disease
- Unable to give informed consent of follow-up
- Pregnant or nursing
- Under the age of 18
- History of peripheral artery disease
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Interventions
Subjects will receive a standard clinical dose of a radionuclide for perfusion imaging of the lower extremities before and after revascularization procedures.
Subjects will receive a standard clinical dose of a radionuclide for perfusion imaging of the lower extremities before and after revascularization procedures.
Locations(1)
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NCT03622359