RecruitingPhase 1NCT03630991

Edetate Calcium Disodium or Succimer in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome Undergoing Chemotherapy

Monitoring, Detoxifying, and Rebalancing Metals During Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS) Therapy


Sponsor

M.D. Anderson Cancer Center

Enrollment

58 participants

Start Date

Oct 11, 2018

Study Type

INTERVENTIONAL

Conditions

Summary

This phase I trial studies the side effects and best dose of edetate calcium disodium or succimer in treating patients with acute myeloid leukemia or myelodysplastic syndrome undergoing chemotherapy. Edetate calcium disodium or succimer may help to lower the level of metals found in the bone marrow and blood and may help to control the disease and/or improve response to chemotherapy.


Eligibility

Min Age: 1 Year

Plain Language Summary

Simplified for easier understanding

This trial is testing whether two chelating drugs — edetate calcium disodium (EDTA) and succimer — which work by binding to and removing heavy metals from the body, can help people undergoing chemotherapy for acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS, a condition where the bone marrow doesn't make enough healthy blood cells). **You may be eligible if...** - You are 18 years or older - OR you are between 1 and 17 years old and weigh at least 8 kg (with parent or guardian consent) - You have been diagnosed with AML or MDS and are undergoing chemotherapy - You or your legal representative can understand the study and voluntarily provide consent **You may NOT be eligible if...** - You weigh less than 8 kg (for pediatric patients) - You are unable to understand or consent to the study - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGEdetate Calcium Disodium

Given IV

DIETARY_SUPPLEMENTMultivitamin

Given PO

DRUGSuccimer

Given PO


Locations(1)

M D Anderson Cancer Center

Houston, Texas, United States

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NCT03630991


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