RecruitingNCT03745339

Outcome Inference in the Sensory Preconditioning Task in Opioid-Use Disorder

Outcome Inference in the Sensory Preconditioning Task in Opioid-use Disorder

Sponsor

National Institute on Drug Abuse (NIDA)

Enrollment

150 participants

Start Date

Jun 7, 2019

Study Type

OBSERVATIONAL

Conditions

Drug addiction Opioid-Related Disorders

Summary

Background: People with addictions often find it hard to choose the long-term benefits of abstinence over the short-term effects of using drugs. Researchers think this is partly due to parts of the brain involved in certain types of learning and decision-making. Researchers want to test these basic functions using a simple task with pictures and odors. Objective: To see if performance in a learning task differs between people who have opioid-use disorder and people who don t. Eligibility: Adults 21-60 years old who are willing to fast for at least 6 hours and smell food odors. Those with an opioid-use disorder must either not use for at least 3 weeks or be in treatment. Design: Participants will have 1 visit that will take up to 5 hours. Before the visit, participants will be asked to not eat or drink anything except water for at least 6 hours. At the visit, participants will be checked for signs of intoxication. Participants will give urine and breath samples. Participants will have tests of learning and behavior. They will look at shapes on a computer screen. The shapes will be paired with different food odors. The odors will come from a sterile tube placed under the nose. Participants will have their breathing monitored with a belt around the upper abdomen. About 30 days and 60 days later, participants will be called and asked about their drug use over the past 30 days. ...

Eligibility

Min Age: 21 YearsMax Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This NIH study investigates how people with opioid use disorder (OUD) process information and make decisions — specifically looking at a cognitive task involving scents and rewards. Researchers want to understand if OUD (either in recovery or in treatment) affects learning and inference, which could help improve treatment approaches. The study enrolls healthy volunteers, people in active opioid treatment (buprenorphine or methadone), and people in early abstinence from opioids. You may be eligible if: - You are between 21 and 65 years old - You are willing to fast for 6 hours before the study session and be exposed to food odors - For the abstinent OUD group: You have a history of opioid use disorder (per DSM-5) and have been abstinent from all illicit substances for at least 3 weeks - For the in-treatment OUD group: You are currently enrolled in buprenorphine or methadone treatment for at least 3 weeks on a stable dose - For the healthy control group: You have no history of substance use disorder You may NOT be eligible if: - You have significant problems with your sense of smell (anosmia, dysosmia, or hyposmia) - You have a neurological condition (Parkinson's, stroke, epilepsy, significant TBI, etc.) that could affect task performance - You have an uncontrolled psychiatric disorder in the past 12 months (major depression, OCD, schizophrenia, PTSD) - You are pregnant - You are currently taking medications that cannot be withheld that affect alertness (e.g., barbiturates, benzodiazepines) - You have a severe allergy or intolerance to odors Talk to your doctor about your current medications and whether your medical and psychiatric history would allow safe participation in this study.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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