STTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis

This study tests whether lacosamide — a medication used for nerve pain — can help reduce abdominal pain in people with chronic pancreatitis who are already taking opioids but still experiencing significant pain. It aims to find a safer pain management option for this difficult-to-treat condition. You may be eligible if: - You are 18 or older - You have a suspected or confirmed diagnosis of chronic pancreatitis with ongoing abdominal pain - You have been taking opioids (not methadone or suboxone) for at least 4 weeks for pancreatitis-related pain - Your average pain score is 4 or higher despite opioid use - You are able to swallow tablets - You meet specific blood count and liver/kidney lab requirements You may NOT be eligible if: - Your chronic pancreatitis is classified as indeterminate (YELLOW 1) - You participated in another investigational study in the last 30 days - You required IV opioids in the past 30 days due to rapidly worsening pain - You are allergic to lacosamide, carbamazepine, or oxcarbazepine - You are pregnant or breastfeeding - You have epilepsy or are taking anti-epileptic drugs (other than gabapentin/pregabalin) - You had abdominal surgery or a pain procedure in the last 90 days - You were hospitalized for pancreatitis or pain in the past 30 days - You currently take Suboxone or Methadone - You have had autoimmune or traumatic pancreatitis, or a pancreatic tumor - You have had a solid organ transplant or have HIV/AIDS Talk to your doctor to see if this trial is right for you.