Cardiac Dysfunction in Childhood Cancer Survivors
Prospective Single Center Cohort Study for Early Detection of Cardiac Dysfunction in Childhood Cancer Survivors
University of Bern
500 participants
Feb 13, 2018
OBSERVATIONAL
Conditions
Summary
This multicenter, prospective cohort study evaluates early cardiac dysfunction in adult survivors of childhood cancer. The hypothesis of this study is that cardiac dysfunction can be detected earlier when using speckle tracking echocardiography as novel echocardiographic technique compared to conventional echocardiography.
Eligibility
Inclusion Criteria9
- This prospective cohort study is nested within the Childhood Cancer Registry (ChCR), a national, population-based cancer registry that includes all children and adolescents in Switzerland who were diagnosed with cancer at age 0-20 years. It includes patients diagnosed with leukemia, lymphoma, central nervous system tumors, and malignant solid tumours or Langerhans cell histiocytosis. Childhood cancer survivors have survived at least 5 years from cancer diagnosis.
- Registered in the ChCR
- Formerly treated at the Department of Pediatric Hematology/Oncology of one of five participating centers
- Treated with any chemotherapy and/or chest radiation
- Survived ≥ 5 years since most recent cancer diagnosis (primary cancer, relapse(s), secondary cancer) at time of examination
- Diagnosed at age ≤ 20 years
- ≥ 18 years of age at time of study participation
- Resident in Switzerland
- Written informed consent
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Interventions
Personal history, physical examination including anthropometry with hip/waist-ratio, electrocardiogram, echocardiography, 1-minute-sit-to-stand test, questionnaires on health-related quality of life (SF-36), diet, physical activity, and fatigue
Locations(6)
View Full Details on ClinicalTrials.gov
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NCT03790943