Critical Care Clinical Trials

43 recruitingLast updated: June 18, 2026

There are 43 actively recruiting critical care clinical trials across 23 countries. Studies span Not Applicable, Phase 2, Phase 4. Top locations include Beijing, Beijing Municipality, China, Montreal, Quebec, Canada, Tours, France. Updated daily from ClinicalTrials.gov.


Critical Care Trials at a Glance

43 actively recruiting trials for critical care are listed on ClinicalTrialsFinder across 6 cities in 23 countries. The largest study group is Not Applicable with 20 trials, with the heaviest enrollment activity in Beijing, Montreal, and Tours. Lead sponsors running critical care studies include Lady Davis Institute, Jian-Xin Zhou, and Capital Medical University.

Browse critical care trials by phase

Treatments under study

About Critical Care Clinical Trials

Looking for clinical trials for Critical Care? There are currently 23 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Critical Care trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Critical Care clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 43 trials

Recruiting
Phase 2

Feasibility and Safety of Targeting Neutral vs Liberal Fluid Balance in Traumatic Brain Injured Patients- LIMIT-TBI Trial

Acute brain injuryTraumatic Brain InjuryNeurocritical Care+1 more
Erasme University Hospital88 enrolled3 locationsNCT07625995
Recruiting
Not Applicable

Focused Ultrasound Spleen Stimulation and Inflammation in Septic Shock

Septic ShockCritical CareFocused Ultrasound+2 more
First Affiliated Hospital of Wannan Medical College40 enrolled1 locationNCT06990295
Recruiting
Not Applicable

Impact of Infusion Line Change Frequency on Infectious Complications Related to Central Venous Catheters in the ICU - A Randomized Controlled Trial

Critical Care NursingIntensive Care (ICU)Central Venous Catheter Related Infections+2 more
University Hospital, Angers2,830 enrolled27 locationsNCT07183592
Recruiting

Communication Enhancement Among Ventilated Patients in Intensive Care

Critical Care, Intensive Care
University Hospital, Tours60 enrolled3 locationsNCT07251530
Recruiting

Rehabilitation Practices in Critically Ill Patients Receiving Invasive Mechanical Ventilation in the Intensive Care Unit.

extubation failureQuality of Life (QOL)Mortality+5 more
Universita degli Studi di Genova2,400 enrolled1 locationNCT07093125
Recruiting
Not Applicable

Effect of Semi-elemental Enteral Nutrition on Gastrointestinal Tolerance in Patients With Traumatic Brain Injury.

Traumatic Brain InjuryNeurocritical CareEnteral Feeding Intolerance
Tang-Du Hospital100 enrolled1 locationNCT07092423
Recruiting

Organ Dysfunction Score for Obstetric Patients

SepsisPregnancyPostpartum+2 more
Daniela Vasquez130 enrolled18 locationsNCT07068022
Recruiting
Phase 2

Fentanyl Versus Hydromorphone in Patients on Mechanical Ventilation

Mechanical VentilationSedation and AnalgesiaCritical Care, Intensive Care
Beth Israel Deaconess Medical Center300 enrolled1 locationNCT07224620
Recruiting

UP STUDY - Decipher Persistent Critical Illness Through in Deep Clinical Phenotyping.

Critical IllnessCritical CareCritical Care, Intensive Care+2 more
Lisbon Academic Medical Center - Centro Académico de Medicina de Lisboa7,000 enrolled7 locationsNCT07510776
Recruiting
Not Applicable

The Family-ICU Trial

family engagementVirtual CareCritical Care, Intensive Care+4 more
Lady Davis Institute194 enrolled2 locationsNCT06586541
Recruiting
Not Applicable

Behavioral Health Collaborative Care Model in Post-ICU Clinic Family Pilot

AnxietyDepression - Major Depressive DisorderPTSD+4 more
Medical University of South Carolina150 enrolled1 locationNCT07390786
Recruiting

Metabolomics Study on Postoperative Intensive Care Acquired Muscle Weakness

Muscle WeaknessMetabolomicsCritical Illness+4 more
Technical University of Munich20 enrolled3 locationsNCT03810768
Recruiting

Dosage of Early Rehabilitation of ICU Patients

PhysiotherapyCritical IllnessCritical Care, Intensive Care+2 more
Medical University of Vienna6,000 enrolled1 locationNCT06960642
Recruiting
Phase 4

CReep and Maintenance flUid Sodium Chloride ADministration rEduction in cRitically Ill adultS

Critical IllnessCritical Care, Intensive CareFluid and Electrolyte Imbalance+2 more
University Hospital, Antwerp640 enrolled4 locationsNCT07189091
Recruiting

Timing and Dose of Fluid Deresuscitation in Critically Ill Patients

Fluid OverloadCritical Care, Intensive CareDeresuscitation
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)150 enrolled2 locationsNCT07275658
Recruiting
Not Applicable

Inspiratory Effort-Targeted Pressure Support Ventilation (IT-PSV) Trial

ventilator-induced lung injuryCritical CareAcute Hypoxic Respiratory Failure
Capital Medical University619 enrolled1 locationNCT06526598
Recruiting

Atrial Strain in Septic Shock

Transthoracic echocardiographySeptic ShockCritical Care+5 more
Centre Hospitalier Universitaire, Amiens60 enrolled1 locationNCT06832436
Recruiting
Not Applicable

Fluid Management and Individualized Resuscitation in Sepsis

SepsisShockEmergency Medicine+3 more
University Medical Center Groningen188 enrolled1 locationNCT07009665
Recruiting
Phase 2

A Clinical Trial of Interventions to Support Family Surrogates of Critically Ill Patients

TraumaCritical CareGrief+1 more
Weill Medical College of Cornell University172 enrolled3 locationsNCT05587517
Recruiting

Anesthesia and Critical Care Registry

AnesthesiaCritical Care
Università Vita-Salute San Raffaele30,000 enrolled1 locationNCT06033404