ClinicalTrialsFinder
RecruitingNCT03909477

Longitudinal Study of Xenon-129 MRI Imaging Effects of Cannabis Smoking

Longitudinal Study of Xenon-129 MRI Imaging of Effects of Cannabis Smoking on Lung Structure and Function

Sponsor

Western University, Canada

Enrollment

200 participants

Start Date

Jun 1, 2022

Study Type

OBSERVATIONAL

Conditions

Cannabis UseCannabis SmokingMarijuana SmokingMarijuana Usage

Summary

This is a longitudinal study of the long-term health impact of cannabis smoking on the lungs. Participants will be followed over a period of 3 years, and impacts of cannabis smoking on the lungs will be measured with magnetic resonance imaging (MRI) using hyperpolarized xenon-129 gas, pulmonary function tests, exercise capacity, computed tomography images and questionnaires.

Eligibility

Min Age: 18 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This study uses a special type of MRI with inhaled xenon gas to examine how the lungs of cannabis smokers look and function over time, helping researchers understand the long-term respiratory effects of cannabis use. **You may be eligible if...** - You are between 18 and 85 years old - You currently smoke or have previously smoked cannabis (medical or recreational), with or without tobacco - You can hold your breath for about 16 seconds - Your lung function tests meet the minimum requirements **You may NOT be eligible if...** - You are pregnant or trying to become pregnant - You have a medical condition that makes participation unsafe - Your breathing is too severely impaired to complete the required tests Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DIAGNOSTIC_TESTHyperpolarized Xenon-129 MRI of the lungs

Participants will be imaged using MRI using hyperpolarized xenon-129 gas as a contrast gas

DIAGNOSTIC_TESTComputed Tomography (CT)

Participants will undergo a CT scan of the thoracic cavity

DIAGNOSTIC_TESTPulmonary Function Tests (PFTs)

Participants will have their lung function evaluated using PFTs

DIAGNOSTIC_TESTSix Minute Walk Test (6MWT)

Participants \>35 years of age will perform the six minute walk test as a measure of exercise capacity

DIAGNOSTIC_TESTCardiopulmonary exercise testing (CPET)

Participants \<35 will perform cardiopulmonary exercise testing as a measure of exercise capacity

DIAGNOSTIC_TESTSputum analysis

Participants will provide a sputum sample that will be analysed for eosinophils

DIAGNOSTIC_TESTBlood analysis

Participants will have their blood drawn and analysed for eosinophil count.

Locations(1)

Robarts Research Institute; The University of Western Ontario; London Health Sciences Centre

London, Ontario, Canada

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT03909477

Related Trials

Neural and Psychiatric Consequences of Cannabis Use in Adolescents

NCT069412982 locations

The Impact of Product Formulation on the Pharmacokinetics and Pharmacodynamics of Cannabis Edibles

NCT056026491 location

Effect of Cannabis on E-Cigarette Use Behavior

NCT066091091 location

Cannabis Effects on Sleep, Circadian Rhythms, and Light Sensitivity in Young Adults

NCT067433731 location

Cannabis-Tobacco Co-Use Treatment Study

NCT068831621 location