RecruitingNCT04076449

Quantitative Susceptibility Biomarker and Brain Structural Property for Cerebral Cavernous Malformation Related Epilepsy

Quantitative Susceptibility Mapping Biomarker, Brain Structure and Connectome Associated With Cerebral Cavernous Malformation Related Epilepsy and Outcome After Surgery


Sponsor

yuanli Zhao

Enrollment

200 participants

Start Date

Sep 3, 2019

Study Type

OBSERVATIONAL

Conditions

Summary

Cerebral cavernous malformation (CCM)-related epilepsy (CRE) impairs the quality of life in patients with CCM. Patients could not always achieve seizure freedom after surgical resection of the lesion, suggesting an inadequate treatment and evaluation of the epileptogenic zone or network. Iron deposition in cerebral cavernous malformations has been postulated to play an important role in triggering CRE. Quantitative susceptibility mapping (QSM), as an optimal in vivo imaging technique to quantify iron deposition, is employed to analyze the iron quantity in CCM patients with epilepsy and further combined with brain structural and connectome analysis, to describe the difference between CCMs with and without epilepsy. In vivo biomarkers predicting CRE risk in CCM natural history and CRE control outcome after CCM surgical resection will be further identified to improve management strategy.


Eligibility

Min Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study is using specialized brain MRI scans to better understand cerebral cavernous malformations (CCMs) — small clusters of abnormal blood vessels in the brain that can cause seizures. Researchers want to find imaging markers that can predict which patients are at greater risk for epilepsy. **You may be eligible if...** - You are between 18 and 70 years old - You have been diagnosed with a single cerebral cavernous malformation (a specific type of abnormal blood vessel cluster in the brain) - You have not had any previous treatment (such as surgery or radiation) for this brain lesion **You may NOT be eligible if...** - You have other brain lesions or tumors besides the CCM - You have had prior brain surgery or brain radiation - You are pregnant or breastfeeding - You have dementia or another progressive brain disease - You cannot have or are unwilling to undergo MRI scans - You are unlikely to return for follow-up visits Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(2)

Beijing Tiantan Hospital, Capital Medical University

Beijing, Beijing Municipality, China

Peking University International Hospital

Beijing, Beijing Municipality, China

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NCT04076449


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