Clinical Utility of WATS3D: A 5-Year Prospective Study

This long-term study is testing whether a new tissue sampling technique called WATS3D (a brush that collects cells from a wide area of the esophagus) can detect Barrett's esophagus or early cancer more accurately than standard forceps biopsies when used together during routine endoscopy. **You may be eligible if...** - You are at least 18 years old - You are having an upper endoscopy (EGD) for heartburn, acid reflux, or to check for Barrett's esophagus - You have known Barrett's esophagus (with or without dysplasia) undergoing surveillance - You have already had treatment to remove Barrett's esophagus and are being monitored - You will undergo both the standard biopsy and the WATS3D brush biopsy during the procedure **You may NOT be eligible if...** - You are pregnant at the time of the procedure - You have unresolved drug or alcohol dependency that prevents you from giving informed consent Talk to your doctor to see if this trial is right for you.