RecruitingNot ApplicableNCT04326192

Brown Adipose Tissue Activation by Spinal Cord Stimulation

Sponsor

Oregon Health and Science University

Enrollment

10 participants

Start Date

Feb 19, 2021

Study Type

INTERVENTIONAL

Conditions

Type 2 Diabetes Obesity, Morbid Pain, Back

Summary

The objective of this study is to investigate and utilize spinal cord stimulation (SCS) as an effective approach to eliciting weight loss and potentially alleviating Type 2 diabetes mellitus (DM), as evidenced by increasing metabolism of adipose tissue.

Eligibility

Min Age: 21 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study is exploring whether spinal cord stimulation — an implanted device used to treat chronic back and leg pain — can also activate a type of body fat called brown adipose tissue, which burns calories and may influence metabolism and weight. Researchers want to understand if pain treatment could have added metabolic benefits. **You may be eligible if...** - You are between 21 and 70 years old - You have persistent neuropathic (nerve-related) back and leg pain - You are already planning to have a spinal cord stimulator implanted to manage your pain - You have a body mass index (BMI) between 25 and 45 **You may NOT be eligible if...** - You have already had a spinal cord stimulator trial - You are taking beta-blocker medications - You have had a significant weight change (more than 5%) in the last 3 months - You smoke or use tobacco regularly - You drink alcohol excessively - You are pregnant - You are a child or adolescent Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEResearch electrode

A second electrode will be placed percutaneously by Tuohy needle in the epidural space at the same time as the SCS trial implant; at lateral T1-2 area randomly assigned to the left or right side of the lateral epidural space, at the time of the procedure. Placement of electrodes is not experimental, but the placement of a second electrode is a research-driven procedure.