Lofexidine Combined With Buprenorphine for Reducing Symptoms of PTSD and OU Relapse in Veterans

This study is testing whether adding a drug called lofexidine to buprenorphine (a medication used to treat opioid use disorder) can help veterans reduce symptoms of PTSD and lower the risk of relapse. Lofexidine is an FDA-approved medication that calms the nervous system and may help with both opioid cravings and PTSD anxiety. **You may be eligible if:** - You are 18 to 70 years old - You can read and understand English - You are currently on a stable dose of buprenorphine (for opioid use disorder) for at least 7 days - You have not been imprisoned, are not a minor, and do not have dementia or a terminal illness **You may NOT be eligible if:** - You are not currently on a stable buprenorphine dose (you may be referred to a program to get stabilized first) - You have conditions that make lofexidine unsafe for you (your doctor will assess this) - You are unable to give informed consent independently Talk to your doctor to see if this trial is right for you.